{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T23:34:49Z","timestamp":1774913689940,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019921","name":"Geistlich Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the efficacy of injectable bone fillers for alveolar ridge preservation (ARP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The mandibular premolars (P2, P3, P4) were bilaterally assigned to ARP in a total of <jats:italic>n<\/jats:italic>\u2009=\u20099 beagle dogs. Each P was decapitated and hemisected under preservation of the mesial (i.e., devitalization and filling with calcium hydroxide) and removal of the distal root. The resulting 6 extraction sockets were randomly allocated to a total of four injectable test materials (i.e., bovine bone particles + porcine collagen, lyophilized materials reconstituted with either blood or saline [T1, T2, T4]; or ready\u2010to\u2010use wet material [T3]) and one control material (collagenated bovine bone mineral) (C) as well as one negative control group (N). Primary wound closure was ensured in all test and C groups. At 12\u2009weeks, dissected blocks were prepared for histomorphometrical analyses. Buccal bone height (BBH) was defined as a primary outcome. Lingual bone height (LBH), buccal and lingual bone wall width (BBW and LBW 1, 3 and 5\u2009mm infracrestally), surface area of bone and particles, fibrous tissues, and bone marrows were defined as secondary outcomes. Between\u2010group comparisons were assessed using ANOVA and Mann\u2013Whitney tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12\u2009weeks, all groups were associated with similar BBH values (BBH: 14.1, 14.0, 13.7, 13.8, 14.3 and 114.2\u2009mm in the T1, T2, T3, T4, C and N groups, respectively; <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05 for all between\u2010group comparisons). The BBW and LBW measurements were comparable among the groups. ARP sites showed a trend towards higher area measurements of bone and particle surfaces compared with the N group (11.5, 11.6, 13.1, 12.5, 9.1\u2009mm<jats:sup>2<\/jats:sup> in T1, T2, T3, T4, C and N groups, respectively). C, T1, T2, T3 and T4 particles were associated with a similar marked grade of osteoconduction and osteointegration within the former extraction socket area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within its limitations, the present study has pointed to the similar efficacy of injectable bone fillers for ARP compared with the particulated bone substitute and negative control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14162","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T02:29:31Z","timestamp":1744338571000},"page":"949-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Injectable Bone Fillers for Alveolar Ridge Preservation: A Histomorphometrical Analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-227X","authenticated-orcid":false,"given":"Frank","family":"Schwarz","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Implantology Goethe University, ZZMK Carolinum  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-1882","authenticated-orcid":false,"given":"Ausra","family":"Ramanauskaite","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implantology Goethe University, ZZMK Carolinum  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Obreja","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implantology Goethe University, ZZMK Carolinum  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department for Oral, Cranio\u2010Maxillofacial and Facial Plastic Surgery Goethe University, University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sader","sequence":"additional","affiliation":[{"name":"Department for Oral, Cranio\u2010Maxillofacial and Facial Plastic Surgery Goethe University, University Hospital Frankfurt  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puria","family":"Parvini","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implantology Goethe University, ZZMK Carolinum  Frankfurt 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