{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:59:43Z","timestamp":1792598383838,"version":"4.5.0"},"reference-count":90,"publisher":"Wiley","issue":"S29","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify host markers with optimal diagnostic performance for clinical implementation in the diagnosis of periodontal diseases and prediction of future disease progression and\/or disease resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional and prospective studies with \u2265\u200920 participants per group, reporting diagnostic accuracy (e.g., area under the curve [AUC]) of host markers for periodontal diagnosis (focused question 1 [FQ1]), periodontitis progression\/relapse (FQ2) or resolution (FQ3) were searched in three electronic databases. Meta\u2010analyses estimating diagnostic accuracy (DA) for individual host markers and for grouped salivary and gingival crevicular fluid (GCF) markers independently were performed whenever two or more studies were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010one eligible studies were identified, of which 13 were included in meta\u2010analyses for FQ1 (discrimination between health and periodontitis). Matrix metalloproteinase\u20108 (MMP\u20108) was the most reported biomarker in both saliva and GCF, with comparable AUC (0.70\u20130.90), sensitivity (0.49\u20130.84) and specificity (0.62\u20130.79) in both sample types. Cytokines had good ability for discrimination of periodontitis\/gingivitis versus health, although they were substantially less accurate for periodontitis versus gingivitis. Combinations of cytokines and MMPs tended to increase overall diagnostic accuracy but without significant improvement in the case of periodontitis\/gingivitis discrimination. Bone markers were the best performing group of salivary markers (AUC\u2009=\u20090.91) when compared to cytokines (AUC\u2009=\u20090.86) and MMPs (AUC\u2009=\u20090.77). GCF microRNAs (MiRs) were a singly meta\u2010analysed group of biomarkers demonstrating AUC\u2009=\u20090.79.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reported studies on host periodontal markers exhibit serious limitations regarding clinical and validation standards, being the main cause for lack of progress in clinical implementation of biomarkers in periodontal classification. Disease\u2010specific markers such as bone markers showed better diagnostic performance (from limited number of studies) for the diagnosis of periodontitis when compared to cytokines and MMPs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14167","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T03:10:08Z","timestamp":1745032208000},"page":"155-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Host Markers of Periodontal Diseases: Meta\u2010Analysis of\u00a0Diagnostic Accuracy Studies"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7093-7956","authenticated-orcid":false,"given":"Mia","family":"Rakic","sequence":"first","affiliation":[{"name":"Robert K. Schenk Laboratory for Oral Histology, Department of Periodontology School of Dental Medicine, University of Bern  Bern Switzerland"},{"name":"Institute for Biological Research \u201cSinisa Stankovic\u201d University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Calciolari","sequence":"additional","affiliation":[{"name":"Centro di Odontoiatria, Dipartimento di Medicina e Chirurgia Universit\u00e0 di Parma  Parma Italy"},{"name":"Centre for Oral Clinical Research, Faculty of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-7266","authenticated-orcid":false,"given":"Melissa M.","family":"Grant","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Oral Rehabilitation Dentistry, School of Health Sciences, College of Medicine and Health, University of Birmingham  Birmingham UK"},{"name":"Periodontal Research Group Dentistry, School of Health Sciences, College of Medicine and Health, University of Birmingham  Birmingham UK"},{"name":"Birmingham's NIHR BRC in Inflammation Research, University of Birmingham; and Birmingham Dental Hospital Birmingham Community Health Foundation Trust  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Radovanovic","sequence":"additional","affiliation":[{"name":"Faculty of Organizational Sciences University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-3556","authenticated-orcid":false,"given":"Nagihan","family":"Bostanci","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-4865","authenticated-orcid":false,"given":"Philip M.","family":"Preshaw","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Dundee  Dundee UK"},{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724\u20106329.23.04778\u20102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010023\u201004991\u20107"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170245"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201024295\u20102"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010023\u201002787\u20105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.2011.01445.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20\u20100406"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.2005.02435.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14936"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_179_23"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2019.03.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201085120\u2010w"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2018.1412258"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18\u20100157"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12995"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010023\u201003584\u2010w"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20\u20100895"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","unstructured":"Deeks J. 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