{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:25:22Z","timestamp":1788009922734,"version":"build-2784847793"},"reference-count":58,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016209","name":"Bilimsel Ara\u015ft\u0131rma Projeleri, Erciyes \u00dcniversitesi","doi-asserted-by":"publisher","award":["TDH\u20102022\u201011928"],"award-info":[{"award-number":["TDH\u20102022\u201011928"]}],"id":[{"id":"10.13039\/501100016209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate whether restoring serum vitamin D levels in a population requiring supplementation affects matrix metalloproteinase\u20109 (MMP\u20109) levels in the gingival crevicular fluid (GCF) of individuals with periodontal health, gingivitis and periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This prospective cohort study enrolled 101 participants with vitamin D deficiency, including those with periodontitis (34) and gingivitis (34) and healthy individuals (33). The periodontal status was evaluated using radiographic and clinical assessments of probing depth, clinical attachment loss, gingival index and plaque index. The analysis of MMP\u20109 levels in the GCF collected from the same dental sites was performed at baseline and 1 month post supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 1\u2009month of vitamin D supplementation, a significant decrease in GCF MMP\u20109 levels was observed across all groups, with the most notable reduction observed in the periodontitis group. The healthy group exhibited the highest percentage reduction at 47%. Linear regression analysis confirmed that changes in vitamin D levels and pocket depth influenced MMP\u20109 alterations in the GCF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Restoration of vitamin D levels in vitamin D\u2010deficient patients to the recommended average level (30 ng\/mL), according to established guidelines,\u00a0led to decreased MMP\u20109 levels in individuals with different periodontal statuses (healthy, gingivitis or periodontitis), potentially mitigating periodontal risks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14175","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T19:28:40Z","timestamp":1747337320000},"page":"1115-1124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Increasing Serum Vitamin D Levels Reduces Gingival Crevicular Fluid Matrix Metalloproteinase\u20109 Levels in Periodontal Health and Diseases"],"prefix":"10.1111","volume":"52","author":[{"given":"Vusal","family":"Gurbanov","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dentistry Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayla","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry Erciyes University  Kayseri T\u00fcrkiye"},{"name":"Department of Periodontology, School of Dentistry Ankara University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Do\u011fruel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Sara\u00e7o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine 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