{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T19:27:45Z","timestamp":1783798065114,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071117"],"award-info":[{"award-number":["82071117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the efficacy of the modified minimally invasive surgical technique (M\u2010<jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content>) combined with a collagen\u2010enriched bovine\u2010derived xenograft (<jats:styled-content style=\"fixed-case\">CEBDX<\/jats:styled-content>) for the treatment of isolated interdental intrabony defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This is a randomized controlled trial including 40 isolated interdental intrabony defects in 40 patients. The test group received M\u2010MIST and CEBDX, and the control group received M\u2010MIST alone. Re\u2010evaluations were performed 1 and 2\u2009years after surgery, with probing depth (PD) and clinical attachment level (CAL) measured at the buccal\/labial and lingual\/palatal sides of the defects as at baseline. Periapical radiographs and CBCT were also performed to evaluate the radiographic bone changes of the defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight defects were evaluated at the 1\u2010 and 2\u2010year follow\u2010ups, and both groups showed statistically significant improvements in PD, CAL and radiographic bone volume. The test group exhibited increased PD reduction (3.95\u2009\u00b1\u20091.39\u2009mm vs. 2.95\u2009\u00b1\u20091.51\u2009mm, <jats:italic>p<\/jats:italic>\u2009=\u20090.041) and CAL gain (3.58 vs. 2.53\u2009mm on average, <jats:italic>p<\/jats:italic>\u2009=\u20090.043) at the buccal side of the defects. No difference was found at the lingual side. A significantly greater radiographic bone volume gain (17.77\u2009\u00b1\u200911.44\u2009mm<jats:sup>3<\/jats:sup> vs. 8.63\u2009\u00b1\u20097.10\u2009mm<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.011) was found in the test group at the 2\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>M\u2010MIST was effective both alone and with CEBDX. The addition of CEBDX significantly improved radiographic bone volume gain and PD reduction, and CAL gain at the buccal side of the defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14178","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T06:02:32Z","timestamp":1747634552000},"page":"1147-1157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Randomized Controlled Study on the Treatment of Isolated Interdental Intrabony Defects Using the Modified Minimally Invasive Surgical Technique With or\u00a0Without a Collagen\u2010Enriched Bovine\u2010Derived Xenograft: A 2\u2010Year Analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4603-6474","authenticated-orcid":false,"given":"Yuzhe","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, NHC Research Center of Engineering and Technology for Computerized Dentistry  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, NHC Research Center of Engineering and Technology for Computerized Dentistry  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-7138","authenticated-orcid":false,"given":"Churen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, NHC Research Center of Engineering and Technology for Computerized Dentistry  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, NHC Research Center of Engineering and Technology for Computerized Dentistry  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry Peking University School and Hospital of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, NHC Research Center of Engineering and Technology for Computerized Dentistry  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0937-2807","authenticated-orcid":false,"given":"Pierpaolo","family":"Cortellini","sequence":"additional","affiliation":[{"name":"Private Practice  Florence Italy"},{"name":"European Research Group on Periodontology (ERGOPERIO)  Bern Switzerland"},{"name":"Section of Periodontology Department of Oral Health Sciences, KU Leuven &amp; 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