{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:10:19Z","timestamp":1787771419851,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the clinical response to Non\u2010Surgical Periodontal Therapy (NSPT) between suprabony and intrabony defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Totally 200 NSPT patients' records from the King's College London\u2014Oral, Dental and Craniofacial Biobank were included. Periapical radiographs of sites with Periodontal Probing Depth (PPD)\u2009&gt;\u20094\u2009mm were assessed. Changes in periodontal measurements between baseline and three\u2010month re\u2010evaluation were examined and compared across suprabony and intrabony sites. Multilevel analysis was carried out to assess the relative contribution of site\u2010, tooth\u2010, patient\u2010 and treatment\u2010related factors on the clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although intrabony defects showed higher PPD reduction after NSPT compared with suprabony defects, this was a function of initial deeper PPD. In fact, suprabony defects outperformed intrabony defects for \u2018pocket closure\u2019 at every initial PPD threshold and overall were 2.60 times more likely to achieve \u2018pocket closure\u2019. Defect morphology was one of several factors affecting treatment outcomes. The relative contribution to \u2018pocket closure\u2019 was 64.9% for site\u2010, 26.1% for patient\u2010, 9.0% for tooth\u2010 and 1% for treatment\u2010related factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bone defect morphology influences clinical outcome of NSPT, with suprabony defects being twice as likely to achieve pocket closure and resulting in 0.6\u2009mm more PPD reduction compared with intrabony defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14181","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:11:20Z","timestamp":1747721480000},"page":"1158-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Differential Response to Non\u2010Surgical Periodontal Therapy Between Intrabony and Suprabony Defects: A Retrospective Analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-5139","authenticated-orcid":false,"given":"Alessandro","family":"Cuozzo","sequence":"first","affiliation":[{"name":"Periodontology Unit Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London  London UK"},{"name":"Periodontology Unit, Department of Neuroscience, Reproductive and Odontostomatological Sciences University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mishika","family":"Arora","sequence":"additional","affiliation":[{"name":"Periodontology Unit Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-2644","authenticated-orcid":false,"given":"Lorenzo","family":"Marini","sequence":"additional","affiliation":[{"name":"Periodontology Unit Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London  London UK"},{"name":"Section of Periodontics, Department of Oral and Maxillofacial Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Hurley","sequence":"additional","affiliation":[{"name":"Periodontology Unit Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Malaki","sequence":"additional","affiliation":[{"name":"Periodontology Unit Centre for Host Microbiome Interactions, Faculty of Dentistry, 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-5010","authenticated-orcid":false,"given":"Luigi","family":"Nibali","sequence":"additional","affiliation":[{"name":"Periodontology Unit Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","first-page":"229","article-title":"Problems and Proposals for Recording Gingivitis and Plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental 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