{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:13:12Z","timestamp":1791663192887,"version":"4.3.4"},"reference-count":70,"publisher":"Wiley","issue":"S29","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["01\u201011\u20102021"],"award-info":[{"award-number":["01\u201011\u20102021"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["01\u201011\u20102024"],"award-info":[{"award-number":["01\u201011\u20102024"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine the accuracy of microbiological biomarkers in diagnosing periodontal diseases, specifically addressing three focus questions: (FQ1) distinguishing health from disease; (FQ2) predicting disease progression; and (FQ3) assessing treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A PRISMA\u2010guided search in MEDLINE, EMBAS and WEB OF SCIENCE included cross\u2010sectional and longitudinal studies (e.g., randomised controlled trials, cohort studies) with \u2265\u200920 participants per group. Eligible studies involved individuals diagnosed with periodontal health, gingivitis or periodontitis, based on well\u2010defined clinical criteria, and utilised microbiological analyses of oral fluids and\/or dental plaque. Diagnostic accuracy had to be evaluated using sensitivity, specificity or area under the receiver operating characteristic (ROC) curve (AUC), or alternatively, data for their computation had to be provided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010one studies were included, mostly cross\u2010sectional or case\u2013control, with significant variability in sampling sites, microbial analyses and diagnostic definitions, complicating direct comparisons. Frequently investigated biomarkers included\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>\n                      <\/jats:styled-content>\n                      (JP2 genotype),\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Tannerella forsythia<\/jats:italic>\n                      <\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Treponema denticola<\/jats:italic>\n                      <\/jats:styled-content>\n                      . The highest diagnostic accuracy (AUC &gt;\u20090.95) was achieved through composite microbiome\u2010based metrics such as the subgingival microbial dysbiosis index. However, methodological heterogeneity and inconsistent criteria limited reliability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although microbiological biomarkers hold promise for periodontal disease diagnostics and monitoring, current evidence is insufficient for clinical implementation. Future research should standardise methodologies, sampling protocols and diagnostic criteria to ensure robust validation and facilitate integration into precision dentistry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.14183","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T19:20:11Z","timestamp":1748200811000},"page":"125-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Microbial Markers for Diagnosis and Risk Assessment for\u00a0Periodontal Diseases: A Systematic Literature Search and Narrative Synthesis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-3556","authenticated-orcid":false,"given":"Nagihan","family":"Bostanci","sequence":"first","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine Karolinska Institutet  Stockholm 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