{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:42:37Z","timestamp":1781617357548,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021\u201003528"],"award-info":[{"award-number":["2021\u201003528"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study investigated the diagnostic potential of salivary triggering receptor expressed on myeloid cells (TREM)\u20101, peptidoglycan recognition protein 1 (PGLYRP1) and interleukin (IL)\u20101\u03b2 for periodontitis patients and their ability to predict treatment outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systemically healthy, non\u2010smokers with gingivitis (<jats:italic>n<\/jats:italic>\u2009=\u200931), stage III periodontitis (34 grade B: <jats:italic>n<\/jats:italic>\u2009=\u200934, grade C: <jats:italic>n<\/jats:italic>\u2009=\u200924) and healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u200934) were recruited. Periodontitis patients (<jats:italic>n<\/jats:italic>\u2009=\u200942) underwent non\u2010surgical periodontal treatment. Saliva was collected at baseline (T0) and post\u2010treatment (T1, T3, T6). Biomarkers were measured using immunoassays. Periodontitis patients were categorised into responders (<jats:italic>n<\/jats:italic>\u2009=\u200919) and non\u2010responders (<jats:italic>n<\/jats:italic>\u2009=\u200923) based on the number of residual pockets \u2265\u20095\u2009mm with bleeding on probing at T6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TREM\u20101 was higher in periodontitis than in gingivitis and health, and in periodontitis grade B than in gingivitis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). PGLYRP1 and IL\u20101\u03b2 were higher in periodontitis and gingivitis compared to controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). All biomarkers discriminated periodontitis from health (AUC \u2265\u20090.9) with high sensitivity (82.1%\u201392.8%) and specificity (83.3%\u201388.9%). TREM\u20101 differentiated periodontitis from gingivitis (AUC\u2009=\u20090.72) with high sensitivity (92.8%) but low specificity (58.1%). Baseline biomarkers did not predict treatment outcome (AUC \u2264\u20090.61), while T1 levels showed moderate potential (AUC \u2265\u20090.71).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Salivary TREM\u20101 pathway biomarkers offer diagnostic value for periodontitis, are modulated by therapy but show limited ability to predict treatment outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Registration<\/jats:title><jats:p>The study has been registered in <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> (ID: NCT06715176, 4 December 2024).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14195","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:43:36Z","timestamp":1750211016000},"page":"1288-1297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>TREM<\/scp>\u20101 Pathway Biomarkers for Classification of\u00a0Periodontal Diseases and Monitoring of Treatment Response in Grade B and C Periodontitis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3717-6969","authenticated-orcid":false,"given":"Angelika","family":"Silbereisen","sequence":"first","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0297-5138","authenticated-orcid":false,"given":"Ronaldo","family":"Lira\u2010Junior","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnostics and Surgery, Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beral","family":"Afacan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgen\u2010Veli","family":"\u00d6zturk","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclnur","family":"Emingil","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry \u0130stinye University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-3556","authenticated-orcid":false,"given":"Nagihan","family":"Bostanci","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine Karolinska Institutet  Stockholm 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