{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T21:09:45Z","timestamp":1781125785521,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the efficacy of copine7\u2010derived peptide (CPNE7\u2010DP) applied in conjunction with non\u2010surgical dental treatments in improving naturally occurring periodontitis in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study included 24 client\u2010owned dogs with mild to moderate periodontitis, randomly assigned to three groups: CPNE7\u2010DP; a placebo control group receiving carrier material; and a negative control group left untreated. Experimental agents were applied after professional dental cleaning. Clinical assessments were conducted at Weeks 0, 4 and 8, which involved measurements of gingival index (GI), periodontal pocket depth (PPD), clinical attachment loss (CAL) and bleeding on probing (BoP). Alveolar bone loss (ABL) was evaluated using intraoral radiographs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Application of CPNE7\u2010DP resulted in a significant improvement in GI, PPD, CAL and BoP compared with both placebo and negative control groups. ABL was significantly reduced in the CPNE7\u2010DP group. These clinical outcomes indicated the potential regenerative effects of CPNE7\u2010DP on periodontal tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical application of CPNE7\u2010DP in conjunction with non\u2010surgical dental treatments was effective in reducing gingival inflammation, PPD, CAL and ABL in dogs with naturally occurring periodontitis. These findings suggest the potential of CPNE7\u2010DP as an effective adjunctive therapeutic agent for periodontal treatment.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> Approved by the Institutional Animal Care and Use Committee of Seoul National University (SNU\u2010220520\u20105\u20101)<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14200","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T22:29:52Z","timestamp":1751840992000},"page":"1491-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the Clinical Efficacy of Copine 7\u2010Derived Peptides for Naturally Occurring Periodontitis in Dogs"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2391-2435","authenticated-orcid":false,"given":"Se Eun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonu","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehan","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhee","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Seol","family":"Lee","sequence":"additional","affiliation":[{"name":"Regenerative Dental Medicine R&amp;D Center, HysensBio Co., Ltd.  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