{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T23:16:28Z","timestamp":1772061388252,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether the systemic inflammatory response against inflammatory conditions in the periodontium is related to serum apolipoprotein B (ApoB) and A1 (ApoA1) concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The study consisted of the Health 2000 Survey participants (<jats:italic>n<\/jats:italic>\u2009=\u20092709) aged 30\u201349\u2009years. The inflammatory condition of the periodontium was assessed by means of the number of teeth with deepened (\u2265\u20094\u2009mm) and deep (\u2265\u20096\u2009mm) periodontal pockets. Systemic inflammation was measured by serum C\u2010reactive protein (CRP) levels. The role of ApoB and ApoA1 was studied by performing regression analyses and stratified analyses (according to the median values).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In logistic regression analyses, the number of teeth with deepened (\u2265\u20094\u2009mm) periodontal pockets was associated with serum CRP levels among those participants whose serum ApoB concentration was \u2265\u20091.12\u2009g\/L. When the participants' ApoB concentration was &lt;\u20091.12\u2009g\/L, such an association between deepened periodontal pockets and CRP was not observed. The direction or strength of the association between periodontal pockets and CRP was not essentially different in the ApoA1 strata.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Systemic response against poor periodontal condition varied between individuals. The variation appeared to be related more to the serum concentration of ApoB than ApoA1.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.14202","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T23:58:48Z","timestamp":1752191928000},"page":"1454-1465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Periodontal Condition With Serum C\u2010Reactive Protein Levels: The Role of Serum Apolipoproteins' Concentration"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3360-6877","authenticated-orcid":false,"given":"Anniina","family":"Haro","sequence":"first","affiliation":[{"name":"Institute of Dentistry University of Eastern Finland  Kuopio Finland"},{"name":"Oral and Maxillofacial Diseases Teaching Unit Kuopio University Hospital  Kuopio North Savo Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-7425","authenticated-orcid":false,"given":"Tuomas","family":"Saxlin","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Eastern Finland  Kuopio Finland"},{"name":"Oral and Maxillofacial Diseases Teaching Unit Kuopio University Hospital  Kuopio North Savo Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-0055","authenticated-orcid":false,"given":"Anna Liisa","family":"Suominen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Eastern Finland  Kuopio Finland"},{"name":"Oral and Maxillofacial Diseases Teaching Unit Kuopio University Hospital  Kuopio North Savo Finland"},{"name":"Welfare Epidemiology and Monitoring Unit Finnish Institute for Health and Welfare  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3522-5301","authenticated-orcid":false,"given":"Antti","family":"Jula","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare (THL)  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1957-7577","authenticated-orcid":false,"given":"Pekka","family":"Yl\u00f6stalo","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health, Faculty of Medicine University of Oulu  Oulu Finland"},{"name":"Department of Oral and Maxillofacial Surgery Oulu University Hospital  Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and Oulu University  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Aromaa A. andS.Koskinen eds.2004.\u201cHealth and Functional Capacity in Finland.\u201dBaseline. 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