{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:58:48Z","timestamp":1793134728983,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The humoral immune system is implicated in the link between periodontitis and atherosclerosis. This study aims to explore how interactions between the oral microbiota and humoral immune responses may contribute to this association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We analysed data from the Northern Finland Birth Cohort 1966, which included 1560 participants who underwent comprehensive health and oral examinations. Serum antibodies against phosphorylcholine (PCho) and malondialdehyde acetaldehyde (MAA) adducts were measured using chemiluminescence immunoassays. In a sub\u2010cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009868), the oral microbiome from saliva samples was characterised using 16S rRNA gene sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher serum levels of IgA and IgG to PCho, as well as IgA to MAA, were associated with an increased number of teeth with probing pocket depths (PPD) \u2265\u20094\u2009mm. Several oral bacterial species, including <jats:styled-content style=\"fixed-case\">\n<jats:italic>Prevotella dentalis<\/jats:italic>\n<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">\n<jats:italic>Filifactor alocis<\/jats:italic>\n<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">\n<jats:italic>Treponema denticola<\/jats:italic>\n<\/jats:styled-content>, correlated with both PPD \u2265\u20094\u2009mm and IgA\/IgG responses to PCho. Mediation analysis, adjusted for periodontitis risk factors, identified <jats:italic>F. alocis<\/jats:italic> as a mediator linking elevated plasma IgG to PCho with the number of teeth with PPD \u2265\u20094\u2009mm. Additionally, individuals harbouring <jats:italic>F. alocis<\/jats:italic> exhibited increased carotid intima\u2010media thickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that <jats:italic>F. alocis<\/jats:italic> may serve as a microbial link between periodontitis and atherosclerosis. Future mechanistic studies should investigate how <jats:italic>F. alocis<\/jats:italic> induces systemic IgG responses and contributes to atherosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.70001","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T01:19:56Z","timestamp":1755047996000},"page":"1550-1559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oral Microbiota Linking Humoral Response, Periodontitis and Atherosclerosis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1783-5330","authenticated-orcid":false,"given":"Ramin","family":"Akhi","sequence":"first","affiliation":[{"name":"Medical Microbiology and Immunology, Research Unit of Biomedicine and Internal Medicine, University of Oulu  Oulu Finland"},{"name":"Oral and Maxillofacial Diseases, University of Helsinki  Helsinki 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