{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:54:46Z","timestamp":1793663686915,"version":"4.5.1"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170968"],"award-info":[{"award-number":["82170968"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20314"],"award-info":[{"award-number":["U22A20314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504200"],"award-info":[{"award-number":["2022YFC2504200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010037","name":"Chongqing Municipal Youth Science and Technology Talent Training Project","doi-asserted-by":"publisher","award":["YXQN202401"],"award-info":[{"award-number":["YXQN202401"]}],"id":[{"id":"10.13039\/501100010037","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the interplay between oxidative stress and gut microbiota in the pathogenesis of increased periodontitis in diabetic mice and explore potential therapeutic strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Diabetic periodontitis (DP) mouse models were established and subjected to interventions including antioxidant treatment, co\u2010housing experiments and faecal microbiota transplantation (FMT). Alveolar bone loss, periodontal inflammation, oxidative stress markers, gut microbiota composition and intestinal barrier function were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diabetes exacerbated alveolar bone loss and inflammation markers in mice with periodontitis. DP mice exhibited significantly elevated systemic oxidative stress and gut dysbiosis compared to controls. Curcumin treatment effectively improved these parameters. Co\u2010housing experiments between curcumin\u2010treated and untreated DP mice showed that beneficial gut microbiota could be transferred between cage mates, leading to improved periodontal outcomes in untreated mice. Additionally, FMT from healthy donors reduced alveolar bone loss and periodontal inflammatory markers while improving oxidative stress parameters and restoring gut microbiota balance and barrier function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that the interaction between oxidative stress and gut dysbiosis may form a pathogenic loop associated with the exacerbation of periodontitis in diabetic conditions. The successful outcomes of antioxidant treatment and FMT suggest multiple adjunctive therapeutic approaches for managing DP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.70003","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T05:50:14Z","timestamp":1754373014000},"page":"1626-1638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oxidative Stress and Gut Microbiota Interplay Exacerbates Periodontitis in Diabetic Mice"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-2493","authenticated-orcid":false,"given":"Haotian","family":"Gong","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Tang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0224-6640","authenticated-orcid":false,"given":"Jinlin","family":"Song","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Stomatological Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2021.102321"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.07.017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201801214"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aal5068"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201006628\u20101"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10050708"},{"issue":"1","key":"e_1_2_10_8_1","first-page":"29","article-title":"Identification of a Cell\u2010Wall Channel in the Corynemycolic Acid\u2010Free Gram\u2010Positive Bacterium Corynebacterium amycolatum","volume":"12","author":"D\u00f6rner U.","year":"2009","journal-title":"International Microbiology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010020\u20100433\u20109"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2401654"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2082145"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2291164"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12270"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4056\/sigs.1714269"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12318"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010023\u201001535\u20109"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12430"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u201000488\u20106"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.701681"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1119990"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010018\u20100089\u2010x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.560678"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010016\u20100222\u2010x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8fo02271b"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106476"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4358"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11020276"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13862"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo2366"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600266"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113892010318580240910061534"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.14"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105562"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010019\u20100704\u20108"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01937"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12298"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.09.026"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003832\u20105"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12342"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7fo00932a"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2023.2243651"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12711"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010365"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3318"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100198\u20104"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.874849"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050521"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2023.105507"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105\u2010017\u20100568\u2010y"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.03.032"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c14291"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010022\u201000212\u20101"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.11.001"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3163"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.15058"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11092266"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910623"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.690138"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:28:13Z","timestamp":1760700493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.70003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/jcpe.70003"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.70003","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,4]]},"assertion":[{"value":"2025-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}