{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:09:51Z","timestamp":1792393791615,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To describe the oral characteristics and evaluate the oral health status of patients with\n                      <jats:italic>PTEN<\/jats:italic>\n                      hamartoma tumour syndrome (PHTS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This descriptive cross\u2010sectional study enrolled participants diagnosed with PHTS at Haukeland University Hospital, Bergen, Norway. A comprehensive oral investigation was performed, including clinical dental and periodontal examination, assessments of gingival overgrowth and palate architecture, intraoral radiographs, orthopantomogram and intraoral optical scanning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty PHTS patients (13 females), with a median age of 45\u2009years, participated in the study. A median of 25.5 teeth were present, and a DMFT score of 17 and DMFS score of 58 were recorded. Eleven patients (55%) were diagnosed with periodontitis, with seven classified as stage II, grade B, and four as stage IV, grade C. Nineteen patients (95%) had gingival overgrowth; the median clinical and photographic gingival overgrowth score was 2.0 and 40%, respectively, with 45% of the patients requiring treatment for the condition. Mucosal lesions were a universal finding. Palate height index was 52.0. Eight patients had 13 cancer diagnoses in total.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PHTS patients face significant oral health challenges, including compromised dental and periodontal health, prevalent gingival overgrowth, mucosal lesions and a high\u2010arched palate. The findings highlight oral features that may facilitate early recognition of PHTS and reinforce the importance of integrating oral health care into patient management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70005","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:58:58Z","timestamp":1756774738000},"page":"1698-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oral Characteristics in Individuals With\n                    <i>PTEN<\/i>\n                    Hamartoma Tumour Syndrome"],"prefix":"10.1111","volume":"52","author":[{"given":"Kristian","family":"Nevland","sequence":"first","affiliation":[{"name":"Department of Clinical Dentistry, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ystein","family":"Fardal","sequence":"additional","affiliation":[{"name":"Private Practice  Egersund Norway"},{"name":"Institute of Community Dentistry University of Oslo  Oslo Norway"},{"name":"Institute of Education for Medical and Dental Sciences University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildegunn H\u00f8berg","family":"Vetti","sequence":"additional","affiliation":[{"name":"Western Norway Familial Cancer Center, Department of Medical Genetics Haukeland University Hospital  Bergen Norway"},{"name":"Faculty of Health Studies VID Specialized University  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-3642","authenticated-orcid":false,"given":"Anne Isine","family":"Bolstad","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme\u20102019\u20100065"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12940"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00338"},{"key":"e_1_2_10_6_1","unstructured":"Cignoni P. 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