{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:46:09Z","timestamp":1791549969450,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009624","name":"Yonsei University College of Dentistry","doi-asserted-by":"publisher","award":["6\u20102024\u20100003"],"award-info":[{"award-number":["6\u20102024\u20100003"]}],"id":[{"id":"10.13039\/501100009624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether early re\u2010entry surgery following simultaneous guided bone regeneration (GBR) and implant placement has a negative impact on the outcome of bone regeneration and osseointegration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In the edentulous mandible of six mongrel dogs, buccal peri\u2010implant dehiscence defects\u00a0were\u00a0surgically created. Bone\u2010level implants were placed with GBR, followed by submerged healing. Two experimental groups\u00a0were\u00a0randomly assigned according to the timing of re\u2010entry and healing abutment connection at 2\u2009months (early\u00a0group) and\u00a04\u2009months\u00a0(late group) following GBR. All animals were euthanised 5\u2009months after GBR for histological analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One implant in the late group failed as a result of fibrin incarceration. There was no statistically significant difference between the two groups regarding new bone area (1.98\u2009mm<jats:sup>2<\/jats:sup> [interquartile range, 1.53\u20132.98] and 0.88\u2009mm<jats:sup>2<\/jats:sup> [0.09\u20131.79]; early vs. late group, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.063); bone\u2010to\u2010implant contact (53.80% [40.88\u201363.10] and 54.15% [45.21\u201366.02], early vs. late groups, respectively; <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.999); width and height of the augmented tissue (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05); and peri\u2010implant mucosal dimensions including thickness, height and volume (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early second\u2010stage surgery results in similar bone regeneration, osseointegration and mucosal dimensions as late abutment connection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.70006","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T11:41:27Z","timestamp":1754653287000},"page":"1639-1647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Does Early Re\u2010Entry Surgery Following Simultaneous Guided Bone Regeneration Compromise the Dimension of\u00a0Peri\u2010Implant Tissues?"],"prefix":"10.1111","volume":"52","author":[{"given":"Sung Jin","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Woo","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Hospital, Veterans Health Service Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4172","authenticated-orcid":false,"given":"Ui\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry  Seoul South Korea"},{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12039"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12539"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12763"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13386"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13726"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2020.50.1.14"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2203260163"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100501.2012.02522.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12802"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13068"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.34133\/bmr.0055"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824\u2010015\u20100038\u2010y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13913"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000411"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2012.12.001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515594780"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13030786"},{"issue":"1","key":"e_1_2_10_19_1","first-page":"13","article-title":"Healing 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