{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:43:31Z","timestamp":1788857011952,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2506300"],"award-info":[{"award-number":["2023YFC2506300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470976"],"award-info":[{"award-number":["82470976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2025JC\u2010YBQN\u20101042"],"award-info":[{"award-number":["2025JC\u2010YBQN\u20101042"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the outcomes of non\u2010surgical periodontal therapy (NSPT) alone and NSPT plus adjacent non\u2010impacted third molar (N\u2010M3) removal on second molars (M2s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this prospective split\u2010mouth study, 40 patients with periodontitis who had N\u2010M3s on both sides of the same jaw were enrolled. For each patient, a full\u2010mouth NSPT was performed, with one N\u2010M3 extracted (N\u2010M3\u2212) and the other N\u2010M3 retained (N\u2010M3+). Periodontal clinical parameters, gingival crevicular fluid (GCF) and subgingival plaque samples were measured\/collected before (T0), 3\u2009months after (T1) and 6\u2009months after (T2) the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All M2s showed improved probing depth after treatment. At T1 and T2, M2s in the N\u2010M3\u2212 group yielded better outcomes in periodontal clinical parameters than the N\u2010M3+ group, along with a significant decrease in the abundance of periodontal pathogens such as <jats:styled-content style=\"fixed-case\">\n<jats:italic>Porphyromonas gingivalis<\/jats:italic>\n<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">\n<jats:italic>Prevotella nigrescens<\/jats:italic>\n<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">\n<jats:italic>Fusobacterium nucleatum<\/jats:italic>\n<\/jats:styled-content> in subgingival plaque. At T2, the M2s in the N\u2010M3\u2212 group had significantly lower GCF volume and higher interleukin\u201010 levels than those in the N\u2010M3+ group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Over the 6\u2010month observation period, removal of adjacent N\u2010M3s enhanced the outcome of NSPT for second molars, as demonstrated clinically, immunologically and microbiologically.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> Chinese Clinical Trail Registry (identification number: ChiCTR2300070343). <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\/showproj.html?proj=194830\">https:\/\/www.chictr.org.cn\/showproj.html?proj=194830<\/jats:ext-link> Date of Registration: April 10th, 2023<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.70010","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T01:50:30Z","timestamp":1754963430000},"page":"1616-1625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Impact of Non\u2010Impacted Third Molar Extraction on Non\u2010Surgical Periodontal Therapy for Adjacent Second Molars: A Prospective Split\u2010Mouth Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4304-3808","authenticated-orcid":false,"given":"Rui","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Stomatology, State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases The Fourth Military Medical University  Xi'an People's Republic 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