{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:09:02Z","timestamp":1788206942939,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the potential benefit of using adjunct systemic antibiotics in surgical peri\u2010implantitis treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Six databases were searched (December 2024) for randomised\/non\u2010randomised clinical studies. After duplicate study selection, data extraction and risk\u2010of\u2010bias assessment, random\u2010effects meta\u2010analyses of odds ratios (ORs) or mean differences (MDs) and their 95% confidence intervals (CIs) were performed, followed by the analysis of certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven studies (three randomised and four non\u2010randomised, comprising 595 patients and 1388 implants) were included. Systemic antibiotics were associated with greater short\u2010term treatment success (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095; OR\u2009=\u20092.33; 95% CI: 1.29\u20134.21), bone gain (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094; MD\u2009=\u20090.37\u2009mm; 95% CI: \u20130.68 to \u20130.07), increased bone level stability (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093; OR\u2009=\u20092.73; 95% CI:\u20091.50\u20134.99), reduced bleeding on probing (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096; OR\u2009=\u20090.49; 95% CI: 0.31\u20130.78), reduced suppuration on probing (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093; OR\u2009=\u20090.33; 95% CI: 0.18\u20130.61) and increased gingival recession (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093; MD\u2009=\u20090.18\u2009mm; 95% CI: 0\u20130.36\u2009mm) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Systemic antibiotics seem to benefit only implants with modified surfaces (ORs: modified 4.10 vs. turned 0.79), and event that, without long\u2010term benefits (\u2265\u20093\u2009years). Finally, one trial found that antibiotics probably increased diarrhoea risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Evidence from randomised\/non\u2010randomised studies seems to indicate that systemic antibiotics benefit surgical peri\u2010implantitis treatment, in the short term (1\u20132\u2009years), especially for implants with a modified surface, while data on adverse effects is scarce. No substantial long\u2010term benefits are seen (\u2265\u20093\u2009years). Uncertainty still exists regarding the potential benefit of systemic antibiotics as adjunct to surgical management of peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70021","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:40:37Z","timestamp":1756363237000},"page":"1746-1759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Do Systemic Antibiotics Offer Benefits to the Surgical Treatment of Peri\u2010Implantitis? A Systematic Review With Meta\u2010Analyses"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-5471","authenticated-orcid":false,"given":"Georgios N.","family":"Antonoglou","sequence":"first","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1968-3326","authenticated-orcid":false,"given":"Spyridon N.","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"Clinic of Orthodontics and Pediatric Dentistry, Center for Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Carrillo de Albornoz","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases (ETEP) Research Group, Faculty of Dentistry, University Complutense of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4469-8335","authenticated-orcid":false,"given":"Michael","family":"Payer","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Orthodontics Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-3754","authenticated-orcid":false,"given":"Andreas","family":"Stavropoulos","sequence":"additional","affiliation":[{"name":"Periodontology, Faculty of Odontology University of Malm\u00f6  Malm\u00f6 Sweden"},{"name":"Department of Periodontology Blekinge Hospital  Karlskrona Sweden"},{"name":"Division of Conservative Dentistry and Periodontology University Clinic of Dentistry, Medical University of Vienna  Vienna Austria"},{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","unstructured":"Antonoglou G. 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