{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:45:12Z","timestamp":1788511512904,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To evaluate the 3\u2010year stability of root coverage outcomes following treatment with a coronally advanced flap (\n                      <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>\n                      ) and a volume\u2010stable, cross\u2010linked xenogeneic collagen matrix (\n                      <jats:styled-content style=\"fixed-case\">VCMX<\/jats:styled-content>\n                      ), either soaked in recombinant human platelet\u2013derived growth factor\u2010\n                      <jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">rhPDGF<\/jats:styled-content>\n                      , test arm) or sterile saline (control arm).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Of the original 30 participants in the triple\u2010blind, randomised, placebo\u2010controlled trial, 26 were available for follow\u2010up at 1 and 3\u2009years. The primary outcome was mean root coverage (\n                      <jats:styled-content style=\"fixed-case\">mRC<\/jats:styled-content>\n                      ) at 3\u2009years compared to the 6\u2010month results. Secondary outcomes included complete root coverage, keratinised tissue width, gingival thickness, volumetric and aesthetic changes, patient\u2010reported outcome measures (\n                      <jats:styled-content style=\"fixed-case\">PROMs<\/jats:styled-content>\n                      ) and ultrasonographic tissue properties. Untreated contralateral teeth were also assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 6\u2009months to 3\u2009years,\n                      <jats:styled-content style=\"fixed-case\">mRC<\/jats:styled-content>\n                      decreased by 6.7% in the control arm and 7.5% in the test arm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Over 90% of treated sites maintained a stable gingival margin (\u2264\u20090.5\u2009mm shift). No significant inter\u2010group differences were found for volumetric, aesthetic or\n                      <jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content>\n                      outcomes. Ultrasonography revealed increased tissue elasticity in treated sites. In contrast, untreated contralateral sites showed progressive gingival recession and increased hypersensitivity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Both\n                      <jats:styled-content style=\"fixed-case\">VCMX<\/jats:styled-content>\n                      treatments demonstrated stable clinical and ultrasonographic outcomes over 3\u2009years, while untreated sites showed signs of soft\u2010tissue deterioration.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70030","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T23:00:12Z","timestamp":1757631612000},"page":"1734-1745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Stability of Root Coverage Outcomes After Soft\u2010Tissue Augmentation With a Collagen Matrix With or Without\n                    <scp>rhPDGF<\/scp>\n                    \u2010\n                    <scp>BB<\/scp>\n                    : A 3\u2010Year Triple\u2010Blinded, Randomised, Placebo\u2010Controlled Trial"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4864-3964","authenticated-orcid":false,"given":"Lorenzo","family":"Tavelli","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Division of Periodontology Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Center for Clinical Research and Evidence Synthesis in Oral TissuE RegeneratION (CRITERION)  Boston Massachusetts USA"},{"name":"Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"School of Dentistry Universidad Catolica de Santiago de Guayaquil (UCSG)  Guayaquil Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-6577","authenticated-orcid":false,"given":"Shayan","family":"Barootchi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity, Division of Periodontology Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Center for Clinical Research and Evidence Synthesis in Oral TissuE RegeneratION (CRITERION)  Boston Massachusetts USA"},{"name":"Department of Periodontics &amp; Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-4878","authenticated-orcid":false,"given":"Maria Vera","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Evidence Synthesis in Oral TissuE RegeneratION (CRITERION)  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-155X","authenticated-orcid":false,"given":"Leonardo","family":"Mancini","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Evidence Synthesis in Oral TissuE RegeneratION (CRITERION)  Boston Massachusetts USA"},{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-2104","authenticated-orcid":false,"given":"Hamoun","family":"Sabri","sequence":"additional","affiliation":[{"name":"Department of Periodontics &amp; 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