{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:42:35Z","timestamp":1792107755177,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periodontitis is a common chronic inflammatory disease. However, drug\u2010related risks and underlying molecular mechanisms remain underexplored from large real\u2010world data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We first mined the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify drugs disproportionately associated with periodontitis, using four signal detection algorithms and logistic regression for confounder adjustment. Identified drugs were then mapped to their protein targets via DrugBank, followed by pathway enrichment and protein\u2013protein interaction (PPI) network analysis to explore biological relevance. To assess potential causality, we conducted Mendelian randomisation (MR) using cis\u2010pQTLs from UKB\u2010PPP and deCODE cohorts. Finally, we used single\u2010cell RNA sequencing (scRNA\u2010seq) data from gingival tissue and peripheral blood of periodontitis patients to evaluate cell type\u2013specific expression of candidate causal genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five drugs (actonel, aclasta, aredia, amlodipine and avastin) were significantly positively associated with periodontitis based on FAERS.\n                      <jats:italic>VEGFA<\/jats:italic>\n                      showed an association with disease risk (OR\u2009=\u20091.043,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049) after meta\u2010analysis of two cohorts. scRNA\u2010seq data identified high\n                      <jats:italic>VEGFA<\/jats:italic>\n                      expression in monocytes in both gingival and blood samples of periodontitis patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study uncovered the association between drug and periodontitis and highlighted\n                      <jats:italic>VEGFA<\/jats:italic>\n                      as a potential molecular mediator. Further studies are needed to confirm causality.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70040","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T23:28:59Z","timestamp":1758065339000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacovigilance\u2010Based Identification and Mechanistic Exploration of Periodontitis\u2010Related Drugs"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9513-7669","authenticated-orcid":false,"given":"Wuda","family":"Huoshen","sequence":"first","affiliation":[{"name":"School of Stomatology Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkai","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Stomatology Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunmi","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Stomatology Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7508-6708","authenticated-orcid":false,"given":"Heng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Stomatology Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panyu","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Stomatology Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Stomatology Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Shuai","sequence":"additional","affiliation":[{"name":"School of Stomatology Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Health Caring Industry Sichuan University of Arts and Science  Dazhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endodontics, The Affiliated Stomatological Hospital Southwest Medical University  Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Mucosal Diseases, The Affiliated Stomatology Hospital Southwest Medical University  Luzhou Sichuan China"},{"name":"Luzhou Key Laboratory of Oral &amp; 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