{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:29:32Z","timestamp":1788838172597,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/09740\u20103"],"award-info":[{"award-number":["2019\/09740\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/08953\u20103"],"award-info":[{"award-number":["2019\/08953\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether periodontitis in parents is associated with differences in the faecal microbiome and systemic markers in both themselves and their children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighty participants were divided into four groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920): parents with periodontitis (PP); healthy parents (PC); and their respective children (CP, CC). Clinical periodontal parameters were recorded. Saliva and faecal bacterial DNA were analysed via 16S rRNA sequencing. Salivary lactoferrin, faecal calprotectin, gingival crevicular fluid cytokines (IFN\u2010\u03b3, IL\u201010, IL\u201017, IL\u20101\u03b2, IL\u20104, TNF\u2010\u03b1) and urinary intestinal permeability markers (claudin\u20102, \u20103, \u20104, haptoglobin) were quantified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Parents with periodontitis showed distinct faecal microbiota profiles, which were mirrored in their children and significantly differed from controls. Claudin\u20102 levels were elevated in both PP and CP groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and positively correlated with the oral dysbiosis index and the faecal Firmicutes\/Bacteroidetes ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Parental periodontal health appears to influence the faecal microbiome and systemic markers in the offspring. These findings highlight a potential pathway for oral\u2013gut microbial transmission and its relevance to systemic health, warranting further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70047","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:36:26Z","timestamp":1759995386000},"page":"222-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Familial Patterns of Oral\u2013Gut Dysbiosis and Systemic Markers in Periodontitis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-2547","authenticated-orcid":false,"given":"H\u00e9lvis E. S.","family":"Paz","sequence":"first","affiliation":[{"name":"Division of Periodontics, Department of Prosthodontics and Periodontics, Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas  Campinas Brazil"},{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-4349","authenticated-orcid":false,"given":"Mabelle F.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Prosthodontics and Periodontics, Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila S.","family":"Stolf","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Prosthodontics and Periodontics, Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ssia F.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Diagnosis and Surgery Institute of Science and Technology \u2013 S\u00e3o Paulo State University  S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Silbereisen","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-0729","authenticated-orcid":false,"given":"Mauro P.","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Diagnosis and Surgery Institute of Science and Technology \u2013 S\u00e3o Paulo State University  S\u00e3o Jos\u00e9 dos Campos Brazil"},{"name":"Division of Periodontology, Center of Oral Health Research College of Dentistry \u2013 University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagihan","family":"Bostanci","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-5855","authenticated-orcid":false,"given":"Renato C. 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