{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:54:22Z","timestamp":1789750462097,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001998"],"award-info":[{"award-number":["UL1TR001998"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK020579"],"award-info":[{"award-number":["P30DK020579"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This secondary analysis of a cross\u2010sectional study tested the hypothesis that a salivary biomarker panel (i.e., consisting of 2\u20136 features) could accurately identify periodontitis in persons with Type 2 diabetes (T2DM) compared with non\u2010periodontitis in systemically healthy persons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Salivary concentrations of 12 protein biomarkers and 14 oral microbiome species were evaluated by immunoassays and 16S rRNA sequencing, respectively, from 28 systemically healthy non\u2010periodontitis adults and 28 T2DM patients with periodontitis. Data were analysed for the identification of periodontitis from non\u2010periodontitis using 5\u2010fold cross\u2010validation logistic regression, receiver operating characteristics (ROC) and odds ratios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bacteria showed better predictive value than individual salivary proteins. Two bacteria (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Mycoplasma faucium<\/jats:italic>\n                      <\/jats:styled-content>\n                      ) yielded specificities &gt;\u200990%,\n                      <jats:italic>Prevotella species<\/jats:italic>\n                      yielded high sensitivity (86%) and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Treponema socranskii<\/jats:italic>\n                      <\/jats:styled-content>\n                      demonstrated the top area under the curve (AUC) (0.81). A salivary panel consisting of bacteria (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Selenomonas sputigena<\/jats:italic>\n                      <\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>P.\u2009gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Prevotella nigrescens<\/jats:italic>\n                      <\/jats:styled-content>\n                      ,\n                      <jats:italic>Pr.\u2009dentalis<\/jats:italic>\n                      ) and protein ratios (prostaglandin E2\/tissue inhibitor of metalloproteinase\u20101 or macrophage inflammatory protein\u20101\u03b1\/tissue inhibitor of metalloproteinase\u20101) produced robust diagnostic accuracy (95%) and precision (96.6%) for the detection of periodontitis in T2DM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A salivary panel using bacteria and ratios of host\u2010response biomarkers accurately identified periodontitis in T2DM compared with systemically healthy persons without periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70049","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:59:46Z","timestamp":1760417986000},"page":"190-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Salivary Biomarker Panel That Identifies Periodontitis in\u00a0Persons With Type 2 Diabetes: A Secondary Analysis of a Cross\u2010Sectional 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L.","family":"Ebersole","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences School of Dental Medicine, University of Nevada, Las Vegas  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua D.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Public Health, University of Kentucky  Lexington Kentucky 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