{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:07:52Z","timestamp":1783512472577,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI22C1609"],"award-info":[{"award-number":["HI22C1609"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n \n To test the hypothesis that a volume\u2010stable collagen matrix (\n VCMX<\/jats:styled-content>\n ) can serve as an effective\n rhBMP<\/jats:styled-content>\n \u20102 carrier for bone regeneration while compensating for the volume instability of absorbable collagen sponge (\n ACS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n (i)\n rhBMP<\/jats:styled-content>\n \u20102 release kinetics from\n VCMX<\/jats:styled-content>\n and\n ACS<\/jats:styled-content>\n were measured over 7\u2009days by enzyme\u2010linked immunosorbent assay. (ii) Bilateral sinus augmentations were performed in 15 rabbits using either\n VCMX<\/jats:styled-content>\n or\n ACS<\/jats:styled-content>\n , with or without\n rhBMP<\/jats:styled-content>\n \u20102. After 4\u2009weeks, radiographic and histological analyses were conducted.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The overall release patterns between\n VCMX<\/jats:styled-content>\n and\n ACS<\/jats:styled-content>\n did not differ significantly, although\n VCMX<\/jats:styled-content>\n showed a delayed peak release (at 3\u2009h) compared to\n ACS<\/jats:styled-content>\n (at 10\u2009min). Three\u2010dimensional radiographic analysis showed greater volumetric gains in\n VCMX<\/jats:styled-content>\n groups than in\n ACS<\/jats:styled-content>\n groups, regardless of\n rhBMP<\/jats:styled-content>\n \u20102 loading. Histologically,\n VCMX<\/jats:styled-content>\n \/\n rhBMP<\/jats:styled-content>\n \u20102 group exhibited the largest total augmented area (13.1\u2009\u00b1\u20092.9\u2009mm\n 2<\/jats:sup>\n ). The use of\n rhBMP<\/jats:styled-content>\n \u20102 led to significant increases in new bone area for both\n VCMX<\/jats:styled-content>\n (3.9\u2009\u00b1\u20091.1 vs. 1.6\u2009\u00b1\u20091.3\u2009mm\n 2<\/jats:sup>\n ,\n p<\/jats:italic>\n \u2009=\u20090.003) and\n ACS<\/jats:styled-content>\n (1.8\u2009\u00b1\u20090.8 vs. 1.0\u2009\u00b1\u20090.6\u2009mm\n 2<\/jats:sup>\n ,\n p<\/jats:italic>\n \u2009=\u20090.035). Notably, the proportion of new bone in the total augmented region was comparable between the\n VCMX<\/jats:styled-content>\n \/\n rhBMP<\/jats:styled-content>\n \u20102 and\n ACS<\/jats:styled-content>\n \/\n rhBMP<\/jats:styled-content>\n \u20102 groups (\n p<\/jats:italic>\n \u2009>\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n rhBMP<\/jats:styled-content>\n \u20102\u2010loaded\n VCMX<\/jats:styled-content>\n enhances bone regeneration in sinus augmentation, suggesting that its volume maintenance may contribute to the improved clinical and radiographic outcomes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpe.70054","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:23:29Z","timestamp":1760826209000},"page":"299-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Volume\u2010Stable Collagen Matrix as a Recombinant Human Bone Morphogenetic Protein\u20102 Carrier for Maxillary Sinus Augmentation: An Experimental In\u00a0Vivo Study"],"prefix":"10.1111","volume":"53","author":[{"given":"Chae\u2010Eun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-8036","authenticated-orcid":false,"given":"Seung\u2010Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong\u2010Won","family":"Paeng","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4864-3964","authenticated-orcid":false,"given":"Lorenzo","family":"Tavelli","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9752-5377","authenticated-orcid":false,"given":"David T.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry Seoul South Korea"},{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4172","authenticated-orcid":false,"given":"Ui\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6906-7209","authenticated-orcid":false,"given":"Jae\u2010Kook","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute for Periodontal Regeneration Yonsei University College of Dentistry Seoul South Korea"},{"name":"Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2005.00642.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084051"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.08.018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12174"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2020.0151"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12156"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12518"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.4.605"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12522"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.08.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120785"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13426"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2107"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.102120"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03362-w"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5536"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7141296"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13480"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2204240212"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12737"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13273"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13562"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947\u20102714.109175"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100501.1997.080503.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.22\u20100226"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01581.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12588"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.04.085"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3698.893"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708\u20108208.2005.tb00054.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201241"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12935"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.70054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:38:32Z","timestamp":1769719112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.70054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,18]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jcpe.70054"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.70054","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,18]]},"assertion":[{"value":"2025-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}