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There was increase in the relative abundance of anaerobic bacteria and reduction in aerobic and facultative anaerobic bacteria. Lipopolysaccharide (LPS) concentrations in both blood and the femoral artery were elevated. scRNA\u2010seq showed an increase in fatty acid binding protein 4 (FABP4\n                      <jats:sup>+<\/jats:sup>\n                      ) endothelial cells (ECs). FABP4\n                      <jats:sup>+<\/jats:sup>\n                      ECs were more responsive to LPS, which promoted neutrophil infiltration and T\u2010cell differentiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings identify FABP4\n                      <jats:sup>+<\/jats:sup>\n                      ECs as key mediators in the connection between periodontitis and PADs. The study provides new insights into the systemic effects of periodontitis and offers a basis for developing preventive and therapeutic strategies for periodontitis\u2010associated vascular diseases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70055","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:17:25Z","timestamp":1761070645000},"page":"334-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Periodontitis Induces Arterial Microbiota Shifts and Immune Dysregulation Contributing to Peripheral Vascular Inflammation"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7291-5045","authenticated-orcid":false,"given":"Xuanzhi","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology, Sichuan University  Chengdu Sichuan China"},{"name":"Department of Periodontics West China Hospital of Stomatology, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouzheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; 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