{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:55:28Z","timestamp":1788299728041,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019921","name":"Geistlich Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effect of the adjunctive use of a resorbable collagen membrane in the reconstructive surgical therapy of peri\u2010implantitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Forty\u2010three patients (43 implants) diagnosed with peri\u2010implantitis underwent surgical treatment using a reconstructive approach, which included a bone substitute material with (test) or without (control) a resorbable collagen membrane. Supportive peri\u2010implant treatment was administered biannually during the 3\u2010year follow\u2010up period. Clinical outcomes, such as probing pocket depth (PPD), bleeding on probing (BOP), suppuration on probing (SOP), marginal mucosal level (REC) and keratinised mucosa width (KM), were recorded at baseline, as well as at 6, 12 and 36\u2009months. Radiographic marginal bone levels (MBLs) and patient\u2010reported outcomes (PROs) were also evaluated. The primary outcome was a composite measure consisting of PPD \u2264\u20095\u2009mm, absence of BOP\/SOP and buccal REC of \u2264\u20091\u2009mm. A second composite outcome, termed \u2018disease resolution\u2019, was also assessed, defined as PPD \u2264\u20095\u2009mm, BOP at \u2264\u20091 site and complete absence of SOP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of the 43 participants, 8 were lost to follow\u2010up, 2 experienced implant loss and 1 was surgically re\u2010treated. At\u00a03\u2009years, the composite outcome was achieved for 25.0% of implants (test: 17.6%; control: 27.8%), while disease resolution was achieved for 31.2% (test: 29.4%; control: 27.8%). Overall, PPD and BOP were reduced by 3.6\u2009\u00b1\u20093.2\u2009mm and 37.5%\u2009\u00b1\u200942.1%, respectively. Changes in buccal REC and KM were 0.5\u2009\u00b1\u20091.3 and 1.1\u2009\u00b1\u20091.5\u2009mm, respectively. An overall bone gain (MBL change) of 1.0\u2009\u00b1\u20092.2\u2009mm was observed. PROs were favourable. No statistically significant differences were observed between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adding a collagen membrane to a bone substitute material in the surgical treatment of peri\u2010implantitis did not yield any benefits regarding clinical, radiographic or patient\u2010reported outcomes.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ISRCTN67095066 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.isrctn.com\/ISRCTN67095066\">https:\/\/www.isrctn.com\/ISRCTN67095066<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70057","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:41:16Z","timestamp":1762213276000},"page":"268-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Use of a Resorbable Membrane as an Adjunct to a Xenogeneic Bone Replacement Graft in the Reconstructive Surgical Therapy of Peri\u2010Implantitis: 3\u2010Year Results of a Randomised Clinical Trial"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4195-0729","authenticated-orcid":false,"given":"Carlotta","family":"Dionigi","sequence":"first","affiliation":[{"name":"Department of Periodontology, Institute of Odontology The Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-6379","authenticated-orcid":false,"given":"Erik","family":"Regidor","sequence":"additional","affiliation":[{"name":"Thinking Perio Research Cl\u00ednica Ortiz\u2010Vig\u00f3n PerioCentrum Bilbao  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5172-5165","authenticated-orcid":false,"given":"Anna","family":"Trullenque\u2010Eriksson","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Institute of Odontology The Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1133-6074","authenticated-orcid":false,"given":"Jan","family":"Derks","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Institute of Odontology The Sahlgrenska Academy at University of Gothenburg  Gothenburg 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