{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:32:50Z","timestamp":1793345570535,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004368","name":"Colgate-Palmolive","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the effect of non\u2010surgical periodontal therapy (NSPT) on renal function and glycaemic control in chronic kidney disease (CKD) patients over a 6\u2010month observation period, through a randomised clinical trial (RCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of 53 patients participated: 27 in the intervention group (IG) and 26 in the control group (CG). Outcomes included estimated glomerular filtration rate (eGFR, calculated using serum creatinine or both serum creatinine and cystatin\u2010C), urine albumin to urine creatinine ratio (uACR) and serum high\u2010sensitivity C\u2010reactive protein (hsCRP) levels. Glycaemic control was assessed using HbA1c levels in patients with diabetes mellitus (DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Intra\u2010group \u0394eGFR levels were 10.26\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 11.17\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), depending on the equation used, favouring IG. hsCRP levels were reduced by 84% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to CG; \u0394HbA1c decreased by 0.54% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) at 6\u2009months. uACR was lower but only marginally (not statistically significant) in IG.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite its limitations, this RCT shows that NSPT enhances renal function\u2014increasing eGFR and decreasing hsCRP\u2014and improves glycaemic control in CKD patients with DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70059","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:02:06Z","timestamp":1766473326000},"page":"362-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Periodontal Therapy on Renal Function and Diabetes Control in Patients With Chronic Kidney Disease. A Randomised Controlled Clinical Trial"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1993-1613","authenticated-orcid":false,"given":"Spyridon K.","family":"Kouris","sequence":"first","affiliation":[{"name":"Department of Dentistry, Department of Periodontics National and Kapodistrian University of Athens, School of Health Sciences  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiorgos A.","family":"Bobetsis","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Department of Periodontics National and Kapodistrian University of Athens, School of Health Sciences  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-8923","authenticated-orcid":false,"given":"Sophia","family":"Lionaki","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology National and Kapodistrian University of Athens, School of Health Sciences, Attikon General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis N.","family":"Kanellopoulos","sequence":"additional","affiliation":[{"name":"Laiko General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Maropoulos","sequence":"additional","affiliation":[{"name":"Laiko General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis A.","family":"Koromantzos","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Department of Periodontics National and Kapodistrian University of Athens, School of Health Sciences  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios D.","family":"Protogerou","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinic &amp; Laboratory of Pathophysiology, Cardiovascular Prevention &amp; Research Unit National and Kapodistrian University of Athens, School of Health Sciences  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebus N.","family":"Madianos","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Department of Periodontics National and Kapodistrian University of Athens, School of Health Sciences  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12390"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25\u2010S002"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1806\u201083242010000400013"},{"issue":"8","key":"e_1_2_12_5_1","first-page":"439","article-title":"High\u2010Sensitivity C\u2010Reactive Protein: Clinical Importance","volume":"29","author":"Bassuk S. S.","year":"2004","journal-title":"Current Problems in Cardiology"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11\u2010S.2089"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21\u20100111"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1698853"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12067"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18178910"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12625"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245619"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08\u20100026"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010042921\u2010102135"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8010015"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2018.04.023"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070569"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.09.018"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2010.01578.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2019.09.005"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08270910"},{"key":"e_1_2_12_22_1","first-page":"3899","article-title":"Effects of Nonsurgical Periodontal Therapy on Serum Inflammatory Factor Levels in Patients With Chronic Kidney Disease and Periodontitis","volume":"28","author":"Guo N.","year":"2017","journal-title":"Biomedical Research (India)"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2013.09.001"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103753"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010015\u20100169\u20103"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143413"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000120707.98922.E3"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.12.009"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096411"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010130\u20106\u2010199903160\u201000002"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.02.010"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523\u20101755.2005.00365.x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528693"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13253"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12836"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2017.8.35985"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010018\u20101120\u20104"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1530\/ec\u201021\u20100097"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2007.01173.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00248"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06\u20101184"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255\u2010018\u20101913\u2010y"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303\u20106979.2004.00460.x"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18\u20100006"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12340"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.34067\/kid.0000000000000425"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.17219\/dmp\/136034"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010physiol\u2010031620\u2010095920"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.777890"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12576"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70059","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.70059","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:08:30Z","timestamp":1793344110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.70059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jcpe.70059"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.70059","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]},"assertion":[{"value":"2025-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}