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Clinical and microbiological outcomes were evaluated at 6, 12 and 48\u2009months after surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010three subjects were included, with 40 and 36 completing follow\u2010ups at 12 and 48\u2009months, respectively. Clinical outcomes improved and remained stable over time in both groups. No statistically significant differences were observed between groups for PD reductions at 12 or 48\u2009months. At 48\u2009months,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>P. gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      was detected in 80% (AZI) and 70.6% (MET). At the final visit, no differences in clinical endpoints were observed between patients harbouring\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>P. gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      and those who were not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Slight differences were observed between the groups, with clinical outcomes improving and remaining stable over time following surgical treatment. Neither protocol suppressed\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>P. gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      beyond detection limit 48\u2009months after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70060","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T23:28:59Z","timestamp":1763508539000},"page":"286-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Periodontal Surgery With Adjunctive Systemic Antimicrobials in Patients Harbouring\n                    <scp>\n                      <i>Porphyromonas gingivalis<\/i>\n                    <\/scp>\n                    : A 48\u2010Month Randomised Clinical Trial"],"prefix":"10.1111","volume":"53","author":[{"given":"Ana Carrillo de","family":"Albornoz","sequence":"first","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group. 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