{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:45:11Z","timestamp":1788511511185,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["19\u2010147"],"award-info":[{"award-number":["19\u2010147"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To evaluate the regenerative potential of liquid platelet\u2013rich fibrin (\n                      <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>\n                      ), with and without a volume\u2010stable collagen matrix (\n                      <jats:styled-content style=\"fixed-case\">VCMX<\/jats:styled-content>\n                      ), in periodontal intrabony defects using histological, histometric and micro\u2010\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>One\u2010wall intrabony defects were surgically created in six beagle dogs and treated with either VCMX plus liquid PRF (TG1), liquid PRF alone (TG2), VCMX alone (CG1) or left empty (CG2). After 12\u2009weeks, samples were analysed by micro\u2010CT, histology and histometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Healing was uneventful in all animals. TG1 showed the greatest cementum (4.08\u2009\u00b1\u20090.88\u2009mm) and bone formation (3.42\u2009\u00b1\u20090.70\u2009mm), followed by TG2 (2.92\u2009\u00b1\u20091.13\u2009mm cementum, 3.19\u2009\u00b1\u20090.78\u2009mm bone) and CG1 (2.07\u2009\u00b1\u20091.06\u2009mm cementum, 3.29\u2009\u00b1\u20090.77\u2009mm bone). CG2 exhibited the poorest outcomes (0.84\u2009\u00b1\u20090.74\u2009mm cementum, 2.58\u2009\u00b1\u20090.38\u2009mm bone). Micro\u2010CT confirmed higher bone volume in TG1 and TG2 compared to CG2; however, the difference was not significant. All treatment groups showed significantly greater cementum and bone formation compared to CG2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within its limitations, the present study indicates that (i) liquid PRF, alone or combined with a volume\u2010stable collagen matrix, enhances periodontal regeneration more than open flap debridement alone, and (ii) the combination tends to show the most favourable outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70065","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T03:14:42Z","timestamp":1763954082000},"page":"424-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preclinical Evaluation of the Effect of Liquid Platelet\u2013Rich Fibrin and a Volume\u2010Stable Collagen Matrix on Periodontal Regeneration"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-5249","authenticated-orcid":false,"given":"Jean\u2010Claude","family":"Imber","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-0860","authenticated-orcid":false,"given":"Andrea","family":"Roccuzzo","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"},{"name":"Shanghai Perio\u2010Implant Innovation Center, Institute of Integrated Oral, Craniofacial and Sensory Research, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology, Shanghai Jiao Tong University, National Center of Stomatology, National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-4920","authenticated-orcid":false,"given":"Nikola","family":"Saulacic","sequence":"additional","affiliation":[{"name":"Department of Cranio\u2010Maxillofacial Surgery, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3708-4821","authenticated-orcid":false,"given":"Maria Permuy","family":"Menda\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Santiago de Compostela  Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-9658","authenticated-orcid":false,"given":"S\u0131la Cagr\u0131","family":"Isler","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of 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