{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:32:55Z","timestamp":1793345575551,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007514","name":"Universit\u00e0 di Pisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare acute\u2010phase response and blood pressure levels following full\u2010mouth or quadrant non\u2010surgical periodontal treatment (FM\u2010SRP or Q\u2010SRP) in patients affected by hypertension and periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Forty patients affected by hypertension and periodontitis were enrolled and randomly allocated to either the FM\u2010SRP or Q\u2010SRP group. Periodontal parameters were registered at baseline and 3\u2009months after treatment. Blood samples and vital signs were collected at baseline, 24\u2009h and 3\u2009months after treatment. Primary outcomes were high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) concentration 24\u2009h post operation and the variation in levels of blood pressure (BP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant increase in hs\u2010CRP levels was observed at 24\u2009h, with FM\u2010SRP presenting higher values than Q\u2010SRP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In terms of periodontal outcomes, both treatment regimens proved equally effective. Systolic BP was significantly reduced at days 1 and 90 in both groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), while a 90\u2010day significant decrease in diastolic BP was detected only in the Q\u2010SRP group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Multiple regression analysis suggests that the peak of hs\u2010CRP at 24\u2009h may influence BP reduction at Day 90.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Q\u2010SRP may be preferred in patients affected by hypertension and periodontitis, as a higher post\u2010operative inflammatory response was associated with lower improvements in BP control in the medium term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70068","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:36:20Z","timestamp":1764668180000},"page":"350-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute\u2010Phase Response Following Different Modalities of Non\u2010Surgical Periodontal Treatment in Subjects Affected by Periodontitis and Co\u2010Morbid Hypertension: A Randomised Clinical Trial"],"prefix":"10.1111","volume":"53","author":[{"given":"Morena","family":"Petrini","sequence":"first","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Science University of Chieti  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gennai","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"},{"name":"Sub\u2010Unit of Periodontology, Halitosis and Periodontal Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Marruganti","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"},{"name":"Sub\u2010Unit of Periodontology, Halitosis and Periodontal Medicine University Hospital of Pisa  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