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The participants included 65 comorbidity cases, 29 PIII\/IV\u2010C&lt;\u200935y\u2010only cases, 27 ARM\u2010only cases and 27 controls. Whole\u2010genome genotyping and bi\u2010clustering were used to identify SNP sets associated with each phenotype, and transcriptomic profiling was performed to validate gene expression changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 109 SNP sets, 91 (83.5%) showed \u2265\u200940% comorbidity risk. Fifty\u2010four and 27 SNP sets were significantly associated with PIII\/IV\u2010C&lt;\u200935y and ARM, respectively. Six genotype subnetworks were enriched for neural development and inflammation pathways, particularly IL\u201017 signalling. Transcriptome data confirmed down\u2010regulation of\n                      <jats:italic>KLHL29<\/jats:italic>\n                      ,\n                      <jats:italic>HSF2<\/jats:italic>\n                      and\n                      <jats:italic>COL13A1<\/jats:italic>\n                      in PIII\/IV\u2010C&lt;\u200935y, and a reduction in\n                      <jats:italic>GJA1<\/jats:italic>\n                      expression in comorbidity cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study reveals a shared genetic architecture between PIII\/IV\u2010C&lt;\u200935y and ARM, implicating neural development and inflammatory pathways in their co\u2010occurrence. Key genes such as\n                      <jats:italic>GJA1<\/jats:italic>\n                      may advance mechanistic understanding and support early identification of high\u2010risk individuals.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70071","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:13:42Z","timestamp":1764987222000},"page":"478-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shared Genotypic Architectures of Stage\n                    <scp>III<\/scp>\n                    \/\n                    <scp>IV<\/scp>\n                    Grade C Periodontitis Under 35\u2009Years of Age (Former Aggressive Periodontitis) and Abnormal Root Morphology: A Family\u2010Based Study"],"prefix":"10.1111","volume":"53","author":[{"given":"Xiaoyuan","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dafang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, NMPA Key Laboratory for Dental Materials &amp; Beijing Laboratory of Biomedical Materials  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-508X","authenticated-orcid":false,"given":"Ruifang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian'e","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-818X","authenticated-orcid":false,"given":"Huanxin","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Periodontology Peking University School and Hospital of Stomatology &amp; 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