{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:05:07Z","timestamp":1791605107082,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare non\u2010surgical subgingival re\u2010instrumentation with an oscillating chitosan brush (OCB), with and without a novel chitosan hydrogel (LGX), in residual or recurrent pockets in step 3 or 4 of stage III\u2013IV periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Patients presenting with residual 5\u20138\u2009mm probing pocket depth (PPD) and modified bleeding on probing (mBOP) scores of 2 or 3 at 3\u20138 teeth were randomly assigned to treatment with either an OCB alone or OCB combined with LGX gel. Treatment was repeated at 3 months. Examinations took place at baseline (BL) and at 1 (Tp1), 3 (Tp2) and 6 months (Tp3) thereafter. Primary outcomes comprised changes in PPD, mBOP and pocket closure (PC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010eight patients were included in the analysis. Both treatments resulted in significant PPD and mBOP reductions at all follow\u2010ups. However, sites treated with adjunctive LGX resulted in significantly greater PPD reductions and higher rates of PC compared to OCB alone (Tp2: PPD reductions 1.55 vs. 1.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; PC: 67.1% vs. 46.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; Tp3: PPD reductions 1.73 vs. 1.33,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001; PC: 76.8% vs. 60.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adjunctive LGX gel application enhanced the efficacy of repeated subgingival re\u2010instrumentation with OCB, reducing the need for additional step 3 interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identification number: NCT05773911, first submitted: 2022\u201009\u201015 (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05773911\">https:\/\/clinicaltrials.gov\/study\/NCT05773911<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70086","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:07:49Z","timestamp":1769083669000},"page":"706-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of Residual Pockets in Stage\n                    <scp>III<\/scp>\n                    and\n                    <scp>IV<\/scp>\n                    Periodontitis Using an Oscillating Chitosan Device With or Without a Chitosan Gel\u2014A Randomised Parallel\u2010Arms Clinical Trial"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2160-242X","authenticated-orcid":false,"given":"Ole","family":"Klein","sequence":"first","affiliation":[{"name":"Department of Periodontology, Institute of Clinical Dentistry, Faculty of Odontology University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5831-1253","authenticated-orcid":false,"given":"Maria G.","family":"Balta","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Institute of Clinical Dentistry, Faculty of Odontology University of Oslo  Oslo Norway"},{"name":"Bjerke Tannmedisin  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1952-3800","authenticated-orcid":false,"given":"Johan Caspar","family":"Wohlfahrt","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Institute of Clinical Dentistry, Faculty of Odontology University of Oslo  Oslo Norway"},{"name":"Bjerke Tannmedisin  Oslo 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