{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:56:13Z","timestamp":1773197773112,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005075","name":"Universitair Medisch Centrum Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyse the effect of systemic amoxicillin and metronidazole on surgical peri\u2010implantitis treatment with a follow\u2010up period of 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Fifty\u2010nine patients were randomly assigned to receive peri\u2010implantitis surgery supplemented with (29 patients; test) or without (30 patients; control) systemic amoxicillin and metronidazole, in cases with no, one\u2010wall or two\u2010wall bony defects. Primary outcomes were mean peri\u2010implant probing pocket depth (PPD) and mean peri\u2010implant bleeding on probing (BOP); secondary outcomes included disease resolution (composite treatment outcome: residual probing depths \u2264\u20095\u2009mm; no BOP in one or more probing site; no suppuration on probing), suppuration on probing (SOP) and radiographic marginal bone levels (MBLs), evaluated 3, 6, 9 and 12\u2009months postoperatively (T3, T6, T9, T12). Linear and logistic mixed\u2010effects models were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between\u2010group analyses showed that BOP was significantly lower in the test group compared to the control group at T9 (\u03b2\u2009=\u2009\u221210.57%, 95% CI: \u221220.17 to \u22120.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and T12 (\u03b2\u2009=\u2009\u221214.47%, 95% CI: \u221225.9 to \u22123.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). No other parameters in the mixed\u2010effects models showed statistically significant differences between groups at any timepoint.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Access\u2010flap peri\u2010implantitis surgery supplemented with systemic amoxicillin and metronidazole led to a statistically significant reduction in peri\u2010implant BOP after 1 year, whereas no other parameters showed statistically significant differences between groups at any timepoint. The clinical implications of these differences should be interpreted with caution, as the isolated short\u2010term effect does not translate into broader or sustained clinical benefit and must be weighed against the risks associated with systemic antibiotic use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70100","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:39:07Z","timestamp":1768376347000},"page":"550-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjunctive Systemic Amoxicillin and Metronidazole Following Surgical Peri\u2010Implantitis Treatment: A Single\u2010Blind Randomised Controlled Trial With a 1\u2010Year Follow\u2010Up"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6991-7218","authenticated-orcid":false,"given":"Jarno","family":"Hakkers","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen and University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-462X","authenticated-orcid":false,"given":"Yvonne C. M.","family":"de Waal","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene University Medical Center Groningen and University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barzi","family":"Gareb","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen and University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-6031","authenticated-orcid":false,"given":"Henny J. A.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen and University of Groningen  Groningen the Netherlands"},{"name":"Center for Dentistry and Oral Hygiene University Medical Center Groningen and University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-7141","authenticated-orcid":false,"given":"Gerry M.","family":"Raghoebar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen and University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12387"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520949851"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12010114"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13653"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12813"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12297"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.6935"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj12010020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12805"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13881"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13823"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12492"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102024\u2010081123"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12583"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12047"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2103020151"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.10.1415"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12791"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010021\u201002020\u20101"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.5.961"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4150"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13994"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13711"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04974\u201014"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13773"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.01.024"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u2010051x.2001.028004296.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010015\u20100123\u20106"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010021\u201003869\u2010w"}],"container-title":["Journal 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