{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:41:38Z","timestamp":1791600098111,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371006"],"award-info":[{"award-number":["82371006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071152"],"award-info":[{"award-number":["82071152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501102"],"award-info":[{"award-number":["82501102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M771755"],"award-info":[{"award-number":["2025M771755"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20251217"],"award-info":[{"award-number":["GZC20251217"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the percentage of new bone formation as the primary outcome of bone regeneration at 6\u2009months after maxillary sinus floor elevation (MSFE) using platelet\u2010rich fibrin (PRF) combined with deproteinised bovine bone mineral (DBBM) versus DBBM alone, and to explore the molecular mechanisms through which PRF modulates osteogenesis in the maxillary sinus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Forty patients undergoing MSFE were randomly allocated to two groups: DBBM alone or PRF\u2009+\u2009DBBM. Six months post MSFE, bone core samples were harvested during implant placement. Clinical outcomes included implant stability and postoperative complications. Radiographic analyses quantified graft height and volumetric changes. Bone regeneration was evaluated by micro\u2010computed tomography (micro\u2010CT) and histomorphometry, while osteogenic marker expression was examined using RT\u2010qPCR and immunofluorescence. Proteomic profiling, followed by Western blot validation, was performed to identify signalling pathways associated with PRF\u2010induced osteogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The PRF\u2009+\u2009DBBM group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920; 42 implants) showed significantly higher primary implant stability (71.85\u2009\u00b1\u20094.96 vs. 67.65\u2009\u00b1\u20095.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Histological analysis revealed a significantly greater amount of newly formed bone with improved quality, as indicated by higher new bone formation (28.81%\u2009\u00b1\u20094.41% vs. 22.44%\u2009\u00b1\u20094.40%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and increased bone maturity (57.05%\u2009\u00b1\u20097.76% vs. 49.17%\u2009\u00b1\u20097.09%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) compared to the DBBM group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920; 45 implants). Molecular assays showed up\u2010regulated osteogenic gene and protein expression, with activation of TGF\u2010\u03b2, PI3K\u2013Akt and complement and coagulation cascade pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PRF combined with DBBM resulted in improved new bone formation in the maxillary sinus compared to DBBM\u00a0alone and showed superior healing outcomes, potentially mediated by key growth factors and the complement protein\u00a0C1q.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70103","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:32:05Z","timestamp":1771464725000},"page":"681-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Platelet\u2010Rich Fibrin (PRF) Promotes Maxillary Sinus Bone Regeneration: A Randomised Clinical Trial and Proteomic Analysis"],"prefix":"10.1111","volume":"53","author":[{"given":"Sheng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Oral Implantology, School and Hospital of Stomatology Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center for Stomatology and National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices and Beijing Key Laboratory of Digital Stomatology and National Health Commission Key Laboratory of Digital Technology of Stomatology  Beijing China"},{"name":"Institute of Advanced Clinical Medicine, Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology, School and Hospital of Stomatology Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology, School and Hospital of Stomatology Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology, School and Hospital of Stomatology Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology, School and Hospital of Stomatology Jilin University  Changchun 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