{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:33:05Z","timestamp":1793345585881,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K02658"],"award-info":[{"award-number":["24K02658"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biological ageing is characterised by a gradual decline in physiological functions, resulting in increased susceptibility to diseases and mortality. We investigated the relationship between edentulism and biological ageing among adults in England.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were drawn from participants in the English Longitudinal Study of Ageing who completed three consecutive biennial waves (waves 2\u20133\u20134 or 4\u20135\u20136), yielding 1889 individuals providing 2390 three\u2010wave panel observations (mean age at baseline 68.1; men 47.7%). Edentulism was assessed in waves 3 and 5. Biological ageing was estimated using the Klemera and Doubal method, integrating multiple biomarkers assessed in waves 2, 4 and 6. Linear regression with clustered standard errors was employed to evaluate the association between edentulism and biological age in the subsequent wave (i.e., 2\u2009years after the assessment of edentulism). Models were adjusted for pre\u2010exposure confounders, including biological age, gender, socioeconomic status, existing health conditions and functional limitation assessed in the prior wave (i.e., 2\u2009years before the assessment of edentulism).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants with edentulism exhibited a 5.8\u2010year greater biological age than those with some remaining teeth in the subsequent waves. After adjusting for confounding variables, edentulism was associated with a 0.82\u2010year greater biological age than those with some remaining teeth (95% confidence interval: 0.40\u20131.24) in the subsequent waves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Edentulism was longitudinally associated with a greater biological age. Strategies that incorporate oral health promotion, particularly the prevention of tooth loss, may contribute to healthy ageing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70106","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:04:46Z","timestamp":1770703486000},"page":"752-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Edentulism With Subsequent Biological Age: A Cohort Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6114-5604","authenticated-orcid":false,"given":"Yusuke","family":"Matsuyama","sequence":"first","affiliation":[{"name":"Department of Dental Public Health Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakura","family":"Kiuchi","sequence":"additional","affiliation":[{"name":"Department of Dental Public Health Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Aida","sequence":"additional","affiliation":[{"name":"Department of Dental Public Health Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Adult Oral Health Survey.2021.\u201cSelf\u2010Reported Health of Teeth and Gums.\u201dGOVUK.https:\/\/www.gov.uk\/government\/statistics\/adult\u2010oral\u2010health\u2010survey\u20102021\/adult\u2010oral\u2010health\u2010survey\u20102021\u2010self\u2010reported\u2010health\u2010of\u2010teeth\u2010and\u2010gums."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/EE9.0000000000000049"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211037977"},{"key":"e_1_2_10_5_1","unstructured":"Banks J. G. D.Batty J.Breedvelt et\u00a0al.2024.\u201cEnglish Longitudinal Study of Ageing: Waves 0\u201310 1998\u20132023.\u201d[Data Collection]. 40th Edition. UK Data Serv. 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