{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:27:01Z","timestamp":1789684021850,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the real\u2010world comparative effectiveness of various adjunctive systemic antibiotic regimens in combination with scaling and root planing (SRP) using a large, multi\u2010centre retrospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Electronic health records were used retrospectively to categorise periodontitis patients into \u2018SRP Only\u2019 or \u2018SRP + Antibiotic\u2019 groups based on prescriptions within 7\u2009days of therapy. Primary outcomes included changes in probing depth (PD), clinical attachment level (CAL), percentage of sites with PD \u2265\u20094\u2009mm and bleeding on probing (BOP). Secondary outcomes assessed tooth\u2010level worsening in mobility or furcation status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 3125 patients, the amoxicillin + metronidazole combination was found to be statistically superior to SRP alone for reducing PD, BOP and residual disease burden. It significantly reduced the odds of worsening tooth mobility by 63% and furcation involvement by 50%. While azithromycin and doxycycline improved CAL, the benefits of the amoxicillin + metronidazole combination were most pronounced in Stage III\/IV (severe) periodontitis (\u221211.4% residual burden reduction, OR 4.55 for clinical success), compared to a modest effect in Stage I\/II disease (\u22123.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adjunctive systemic antibiotics, particularly the amoxicillin + metronidazole combination, significantly enhance clinical outcomes in non\u2010surgical periodontitis treatment compared to SRP alone, with the greatest benefits seen in severe disease.<\/jats:p>\n                  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