{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:36:59Z","timestamp":1788979019018,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the efficacy of interventions for treating necrotising periodontal diseases (NPDs), including the management of the acute condition and subsequent therapies targeting sequelae and\/or predisposing factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA guidelines, electronic and manual searches were conducted up to April 2025. Randomised controlled trials (RCTs), controlled clinical trials (CCTs) and case series assessing any therapeutic intervention for NPDs (separating them for acute disease resolution and treatment of the preexisting condition and\/or management of sequelae) were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010five studies were included (18 RCTs, 2 CCTs, 15 case series). Mechanical debridement combined with antiseptic rinses (e.g., chlorhexidine or hydrogen peroxide) constitutes the primary therapeutic approach. Systemic antimicrobials, mainly metronidazole, have also frequently been evaluated and used as adjuncts or monotherapy. Reduced pain, bleeding and ulcer resolution within days were the common findings for all tested interventions. Recent trials explored photodynamic therapy (PDT) as adjuncts, showing short\u2010term clinical and microbiological benefits. Evidence was heterogeneous and of high risk of bias. Only five studies addressed post\u2010acute management, with none of them investigating reconstructive approaches or long\u2010term recurrence prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Management of NPDs relies primarily on mechanical debridement and antiseptics, with systemic antimicrobials reserved for cases with systemic involvement. Adjunctive modalities such as PDT have shown promising results but require further validation. Evidence on reconstructive approaches and recurrence prevention is lacking.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70118","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:05:30Z","timestamp":1773972330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Management of Necrotising Periodontal Diseases: A Systematic Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-8529","authenticated-orcid":false,"given":"Eduardo","family":"Montero","sequence":"first","affiliation":[{"name":"Section of Graduate Periodontology. Faculty of Dentistry University Complutense of Madrid  Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group, University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1681-428X","authenticated-orcid":false,"given":"Nerea","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Section of Graduate Periodontology. Faculty of Dentistry University Complutense of Madrid  Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group, University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2825-2165","authenticated-orcid":false,"given":"Evangelia P.","family":"Zampa","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Alonso","sequence":"additional","affiliation":[{"name":"Section of Graduate Periodontology. Faculty of Dentistry University Complutense of Madrid  Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group, University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-9405","authenticated-orcid":false,"given":"Marion","family":"Arce","sequence":"additional","affiliation":[{"name":"Section of Graduate Periodontology. Faculty of Dentistry University Complutense of Madrid  Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group, University Complutense  Madrid Spain"},{"name":"Department of Conservative Dentistry, Faculty of Dentistry University of Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebus","family":"Madianos","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1978.tb01919.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202300197"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.2880.373"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1953.24.3.187"},{"issue":"4","key":"e_1_2_9_6_1","first-page":"83","article-title":"An Evaluation of Metronidazole in Cases of Acute Necrotizing Ulceromembranous Gingivitis (Vincent's Disease)","volume":"41","author":"Chawla T. 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B.Shea D.O'Connell et\u00a0al.2011.\u201cThe Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Metaanalyses.\u201d"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(90)90298\u20107"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.70118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:05:34Z","timestamp":1773972334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.70118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":47,"alternative-id":["10.1111\/jcpe.70118"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.70118","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jcpe.70118"}}