{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T10:06:27Z","timestamp":1779012387298,"version":"3.51.4"},"reference-count":126,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>In systemically healthy humans with gingivitis, what is the efficacy of active agents compared to negative control\/placebo when used adjunctively to mechanical biofilm control in terms of changes in gingivitis\/bleeding indices and\/or disease resolution in randomised controlled clinical trials (RCTs) with at least 3\u2010months follow\u2010up?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Electronic searches, study selection, data extraction, risk of bias analysis, meta\u2010analyses and certainty of the evidence were performed (GRADE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010two RCTs were included (antiseptics\n                      <jats:italic>n<\/jats:italic>\n                      = 71; systemic intake\n                      <jats:italic>n<\/jats:italic>\n                      = 1). High heterogeneity was found in the definition of gingivitis. Antiseptic agents showed greater reductions in bleeding (%) than control groups at 3 months (\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>comparison<\/jats:sub>\n                      [\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>c<\/jats:sub>\n                      ] = 19; weighted mean differences [WMD] = 10.66%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and 6 months (\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>c<\/jats:sub>\n                      = 20; WMD = 10.79%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Gingivitis resolution was rarely determined. Prevalence of local adverse effect (tooth\u2010related and soft\u2010tissue\u2010related) varied from 0% to 13.1%. Systemic effects were scarcely evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In adults with gingivitis, the adjunctive use of specific antiseptics determined higher reduction of gingival inflammation at 3 months (moderate evidence for stannous fluoride and low\u2010to\u2010very low for chlorhexidine, essential oils or cetylpyridinium chloride [CPC]) and 6 months (moderate for chlorhexidine, low for CPC and very low for essential oils) over placebo\/negative controls. Adverse effects are neither frequently nor extensively reported. Gingivitis resolution is rarely reported and achieved.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70121","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:11:47Z","timestamp":1778577107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Adjunctive Agents in\u00a0the Management of\u00a0Biofilm\u2010Induced Gingivitis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-1416","authenticated-orcid":false,"given":"Elena","family":"Figuero","sequence":"first","affiliation":[{"name":"Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases (ETEP) Research Group, Faculty of Dentistry University Complutense of Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-2046","authenticated-orcid":false,"given":"Crystal","family":"Marruganti","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and of the Critical Area University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9837-5393","authenticated-orcid":false,"given":"Nagore","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases (ETEP) Research Group, Faculty of Dentistry University Complutense of Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4902-7813","authenticated-orcid":false,"given":"Rossana","family":"Izzetti","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and of the Critical Area University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-0360","authenticated-orcid":false,"given":"Jorge","family":"Serrano","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases (ETEP) Research Group, Faculty of Dentistry University Complutense of Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-7306","authenticated-orcid":false,"given":"Filippo","family":"Graziani","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and of the Critical Area University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2006.01013.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20105037.2010.00478.x"},{"issue":"4","key":"e_1_2_11_4_1","first-page":"229","article-title":"Problems and Proposals for Recording Gingivitis and Plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dentistry Journal"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.a41362"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a37384"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290109.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41405\u2010025\u201000294\u2010z"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2003.0167"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690020701"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13203"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070028"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12940"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12366"},{"issue":"1","key":"e_1_2_11_15_1","first-page":"23","article-title":"Increasing Antiplaque\/Antigingivitis Efficacy of an Essential Oil Mouthrinse Over Time: An In\u00a0Vivo Study","volume":"61","author":"Charles C. H.","year":"2013","journal-title":"General Dentistry"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0245"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.11.1016"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111870"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1996.tb02079.x"},{"key":"e_1_2_11_20_1","first-page":"5c","article-title":"Essential Oils in an Antiplaque and Antigingivitis Dentifrice: A 6\u2010Month Study","volume":"13","author":"Coelho J.","year":"2000","journal-title":"American Journal of Dentistry"},{"issue":"7","key":"e_1_2_11_21_1","first-page":"e82","article-title":"Comparative Antiplaque and Antigingivitis Efficacy of a Multipurpose Essential Oil\u2010Containing Mouthrinse and a Cetylpyridinium Chloride\u2010Containing Mouthrinse: A 6\u2010Month Randomized Clinical Trial","volume":"43","author":"Cortelli S. C.","year":"2012","journal-title":"Quintessence International"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12158"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2004.00614.x"},{"issue":"6","key":"e_1_2_11_24_1","first-page":"307","article-title":"Effect Upon Plaque Formation and Gingivitis of a Triclosan\/Copolymer\/Fluoride Dentifrice: A 6\u2010Month Clinical Study","volume":"5","author":"Denepitiya J. L.","year":"1992","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1989.tb01661.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16060862"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.23\u20100361"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1997.tb00490.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12616"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13127"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12674"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13244"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.2.112"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12677"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.22\u20100675"},{"issue":"2","key":"e_1_2_11_38_1","first-page":"134","article-title":"Randomized Controlled Trial of 0.454% Stannous Fluoride Dentifrice to Treat Gingival Bleeding","volume":"33","author":"Gerlach R. W.","year":"2012","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1985.tb00941.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.a32827"},{"issue":"4","key":"e_1_2_11_41_1","first-page":"149","article-title":"Triclosan\/Pyrophosphate Dentifrice: Dental Plaque and Gingivitis Effects in a 6\u2010Month Randomized Controlled Clinical Study","volume":"13","author":"Grossman E.","year":"2002","journal-title":"Journal of Clinical Dentistry"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.8.435"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1986.tb01513.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0110"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.09.011"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.6.352"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.6.359"},{"issue":"3","key":"e_1_2_11_48_1","first-page":"155","article-title":"A 3\u2010Month Randomized Trial Evaluating the Effects of Stannous Fluoride Bioavailability on Gingivitis","volume":"38","author":"He T.","year":"2025","journal-title":"American Journal of Dentistry"},{"issue":"2","key":"e_1_2_11_49_1","first-page":"110","article-title":"Randomized Clinical Trial Assessing Anti\u2010Gingivitis Efficacy of Two Stannous Fluoride Dentifrices and Zinc\/Arginine Dentifrice","volume":"34","author":"He T.","year":"2021","journal-title":"American Journal of Dentistry"},{"issue":"4","key":"e_1_2_11_50_1","first-page":"218","article-title":"The Relative Clinical Efficacy of Three 0.454% Stannous Fluoride Dentifrices for the Treatment of Gingivitis Over 3 Months","volume":"33","author":"He T.","year":"2020","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12047"},{"key":"e_1_2_11_52_1","unstructured":"Higgins J. J.Thomas J.Chandler et\u00a0al.2024.\u201cCochrane Handbook for Systematic Reviews of Interventions Version 6.5.\u201d"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007840100114"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20105037.2010.00492.x"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.4038\/cmj.v60i4.8219"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12510"},{"issue":"1","key":"e_1_2_11_58_1","first-page":"33","article-title":"Six\u2010Month Evaluation of a Sodium Bicarbonate\u2010Containing Toothpaste for Reduction of Established Gingivitis: A Randomized USA\u2010Based Clinical Trial","volume":"29","author":"Jose A.","year":"2018","journal-title":"Journal of Clinical Dentistry"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875\u2010595X.2011.00045.x"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875\u2010595X.2011.00044.x"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3920\/bm2017.0104"},{"issue":"2","key":"e_1_2_11_62_1","first-page":"e5","article-title":"Rapid Antigingivitis Efficacy of a Novel Stannous Fluoride Dentrifice: Results From a 12\u2010Week Randomized Controlled Clinical Trial","volume":"42","author":"Klukowska M.","year":"2021","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.10.617"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1763"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.1993.tb00368.x"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150414"},{"issue":"1","key":"e_1_2_11_67_1","first-page":"3","article-title":"A Modified Gingival Index for Use in Clinical Trials","volume":"8","author":"Lobene R. R.","year":"1986","journal-title":"Clinical Preventive Dentistry"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12392"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17050762"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.2319\/041515\u2010251.1"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.b2403125"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41432\u2010025\u201001163\u20102"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12752"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070622"},{"issue":"4","key":"e_1_2_11_76_1","first-page":"179","article-title":"The Effect of a Toothpaste Containing Aloe Vera on Established Gingivitis","volume":"36","author":"Namiranian H.","year":"2012","journal-title":"Swedish Dental Journal"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12505"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010019\u20102745\u20108"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb01108.x"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1997.tb00239.x"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2005.00860.x"},{"issue":"2","key":"e_1_2_11_84_1","first-page":"81","article-title":"A 12\u2010Week Randomized Clinical Study Investigating the Anti\u2010Gingivitis Efficacy of a 0.454% w\/w Stannous Fluoride Dentifrice","volume":"31","author":"Parkinson C. R.","year":"2018","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010020\u201001079\u20106"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1058"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13690"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100757.2011.00425.x"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12340"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110371"},{"issue":"4","key":"e_1_2_11_91_1","first-page":"91","article-title":"Efficacy of Chlorhexidine, Metronidazole and Combination Gel in the Treatment of Gingivitis\u2013A Randomized Clinical Trial","volume":"14","author":"Pradeep A. R.","year":"2012","journal-title":"Journal of the International Academy of Periodontology"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2007.01099.x"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.1995.tb01772.x"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201033521\u20104"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12072"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.10.014"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.1994.tb00741.x"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1989.tb00860.x"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.1996.tb00576.x"},{"key":"e_1_2_11_101_1","unstructured":"Sch\u00fcnemann H. J.Bro\u017cek G.Guyatt andA.Oxman.2013.\u201cGRADE Handbook for Grading Quality of Evidence and Strength of Recommendations.\u201dThe GRADE Working Group 2013.guidelinedevelopment.org\/handbook."},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12331"},{"issue":"6","key":"e_1_2_11_103_1","first-page":"351","article-title":"Comparative Effectiveness of an Essential Oil Mouthrinse and Dental Floss in Controlling Interproximal Gingivitis and Plaque","volume":"15","author":"Sharma N. C.","year":"2002","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290106.x"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_107_1","first-page":"24a","article-title":"A 6\u2010Month Clinical Study Assessing the Safety and Efficacy of Two Cetylpyridinium Chloride Mouthrinses","volume":"18","author":"Stookey G. K.","year":"2005","journal-title":"American Journal of Dentistry"},{"issue":"4","key":"e_1_2_11_108_1","first-page":"441","article-title":"The Effects of Three Silica Dentifrices Containing Triclosan on Supragingival Plaque and Calculus Formation and on Gingivitis","volume":"43","author":"Svatun B.","year":"1993","journal-title":"International Dental Journal"},{"issue":"4","key":"e_1_2_11_109_1","first-page":"431","article-title":"The Effects of a Silica Dentifrice Containing Triclosan and Zinc Citrate on Supragingival Plaque and Calculus Formation and the Control of Gingivitis","volume":"43","author":"Svatun B.","year":"1993","journal-title":"International Dental Journal"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.1989.tb01617.x"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100722.1989.tb01608.x"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100722.1990.tb00976.x"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.1987.tb02251.x"},{"issue":"6","key":"e_1_2_11_114_1","first-page":"28","article-title":"Reduction of Baseline Gingivitis Scores With Repeated Prophylaxes","volume":"4","author":"Talbott K.","year":"1977","journal-title":"Journal of Preventive Dentistry"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098619854881"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1970.41.41.41"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12517"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00795.x"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1998.tb02462.x"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.1994.tb00748.x"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010014\u20101383\u20102"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12082"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12843"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010016\u20100257\u20101"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1989.0209"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4808315"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.1993.tb00371.x"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.70121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:12:07Z","timestamp":1779009127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.70121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":126,"alternative-id":["10.1111\/jcpe.70121"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.70121","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]},"assertion":[{"value":"2025-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jcpe.70121"}}