{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:18:44Z","timestamp":1778642324488,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effect of a reconstructive procedure during surgical treatment of peri\u2010implantitis in 3\u2010 or 4\u2010wall bone defects on clinical and radiographic outcomes after 1\u2009year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010two patients with peri\u2010implantitis were randomly assigned to surgical treatment with (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927) or without (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) a reconstructive procedure using autologous bone, xenograft and a collagen membrane. Primary outcomes were the mean peri\u2010implant probing depth (PPD) and radiographic marginal bone level (MBL). Bleeding on probing (BoP) was the prespecified primary outcome in the original protocol; the present report emphasises PPD and MBL outcomes relevant to reconstructive treatment. Secondary outcomes included BoP, disease resolution (composite treatment outcome), suppuration (SoP), mid\u2010buccal recession (Midbuc REC) and keratinised mucosa (Midbuc KM). Data were analysed using multilevel mixed\u2010effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mixed\u2010effects models showed that patients in the test group showed enhanced marginal bone levels at all follow\u2010ups (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.85 to \u22121.65\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.04) and less mid\u2010buccal recession (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.06 to \u22121.68\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.01) compared to the control group. No significant differences were observed for PPD, BoP, SoP, Midbuc KM or disease resolution.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While the adjunctive reconstructive procedure did not significantly influence peri\u2010implant PPD, BoP, SoP or disease resolution, it was associated with improved radiographic marginal bone levels and reduced mid\u2010buccal soft\u2010tissue recession.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70123","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:41:20Z","timestamp":1776400880000},"page":"933-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Reconstructive Peri\u2010Implantitis Treatment for 3\u2010 and 4\u2010Wall Bone Defects: A Single\u2010Blind Randomised Controlled Trial With a 1\u2010Year Follow\u2010Up"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6991-7218","authenticated-orcid":false,"given":"Jarno","family":"Hakkers","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen and University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-462X","authenticated-orcid":false,"given":"Yvonne C. M.","family":"de Waal","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene University Medical Center Groningen and University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barzi","family":"Gareb","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen and University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-6031","authenticated-orcid":false,"given":"Henny J. A.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen and University of Groningen  Groningen the Netherlands"},{"name":"Center for Dentistry and Oral Hygiene University Medical Center Groningen and University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-7141","authenticated-orcid":false,"given":"Gerry M.","family":"Raghoebar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen and University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2025suppl1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13653"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12297"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13972"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.qi.a44629"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.6935"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14116"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13881"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13823"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102024\u2010081123"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2103020151"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2022.05.007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1027\/1614\u20101881.1.3.86"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12791"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22\u20100511"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13209"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000839"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.14049"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13513"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12986"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1094428107308906"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12999"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13711"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.34172\/japid.2024.013"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13070"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.70123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:56:46Z","timestamp":1778641006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.70123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jcpe.70123"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.70123","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"2025-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}