{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:56:14Z","timestamp":1781337374962,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371006"],"award-info":[{"award-number":["82371006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202501ZYTS290"],"award-info":[{"award-number":["YDZJ202501ZYTS290"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the underlying mechanism of immune cell crosstalk in periodontal inflammatory ageing and to explore potential pharmaceutical interventions for safely reversing this process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Bovine serum albumin\u2013epigallocatechin gallate\u2013copper nanoparticles (BEC NPs) were synthesised by coating a bovine serum albumin membrane onto an epigallocatechin gallate\u2013copper\u2013phenolic network. BEC NPs' regulatory impacts on the fate of neutrophils and macrophages were evaluated through immunofluorescence staining, PCR, RNA sequencing and Western blot analysis. Their anti\u2010senescence effects on gingival fibroblasts were assessed using cell migration assays and SA\u2010\u03b2\u2010gal staining, while an experimental periodontitis rat model was established to validate the in\u00a0vitro findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Accumulating evidence indicated that pH\u2010responsive nanoparticles alleviated periodontal inflamm\u2010ageing through modulation of neutrophil\u2013macrophage crosstalk. Functional analyses revealed that BEC NPs suppressed neutrophil extracellular trap formation via dual mechanisms: reactive oxygen species scavenging to sustain mitochondrial integrity, and actin cytoskeleton stabilisation to inhibit nuclear translocation of neutrophil elastase and myeloperoxidase. In\u00a0vivo assessment demonstrated that BEC NPs exhibited a favourable biosafety profile and significant therapeutic efficacy in suppressing the progression of periodontal inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study presents a smart nanosystem\u2010based \u2018endogenous homeostasis reconstruction\u2019 strategy, offering\u00a0programmable, early\u2010stage intervention for periodontal inflamm\u2010ageing with considerable clinical translation prospects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70133","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:11:42Z","timestamp":1777878702000},"page":"1031-1045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporally Responsive\n                    <scp>BEC<\/scp>\n                    Nanoplatform Targets Neutrophils to Reprogram Immune Crosstalk and Alleviate Periodontal Inflamm\u2010Ageing in Periodontitis"],"prefix":"10.1111","volume":"53","author":[{"given":"Jiaxin","family":"Luo","sequence":"first","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology Jilin University  Changchun China"},{"name":"Department of Oral Implantology, Hospital of Stomatology Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology Jilin University  Changchun China"},{"name":"Department of Oral Implantology, Hospital of Stomatology Jilin University  Changchun 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