{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:10:39Z","timestamp":1791821439823,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301157"],"award-info":[{"award-number":["82301157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["6230012077"],"award-info":[{"award-number":["6230012077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20295"],"award-info":[{"award-number":["U23A20295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62131015"],"award-info":[{"award-number":["62131015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62476033"],"award-info":[{"award-number":["62476033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore the potential of PerioAI, an artificial intelligence system integrating intraoral scanning and cone\u2010beam CT, to automatically measure gingival margin\u2010to\u2010bone distance (GBD) and convert it into AI\u2010derived probing depth (AI\u2010PD), and to evaluate whether AI\u2010PD may provide additional information to support periodontal clinical decision making when radiographic imaging represents the primary source of available periodontal information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional proof\u2010of\u2010principle study included 53 patients with periodontitis (1298 teeth, 7788 sites). GBD measurements were converted to AI\u2010PD using validated formulas. Clinical decision making (prognosis and treatment planning) was evaluated by one periodontist under three information conditions: (i) orthopantomogram (OPG)\u2009+\u2009original periodontal chart (used to establish the reference clinical decision); (ii) OPG\u2010only; and (iii) OPG\u2009+\u2009AI\u2010PD. Using the reference clinical decision, agreement rates for clinical decisions obtained under the two information conditions (OPG\u2010only and OPG\u2009+\u2009AI\u2010PD) were calculated and compared, and the risk of overtreatment was also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with OPG\u2010only, the OPG\u2009+\u2009AI\u2010PD condition showed higher agreement rate with the reference clinical decision, indicating that PerioAI may provide additional information for clinical decision making. Patient\u2010level average agreement rates increased from 77.6% to 84.7% for prognosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and from 78.2% to 84.3% for treatment planning (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Tooth\u2010level agreement rates improved from 78.1% to 86.0% for prognosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and from 78.8% to 85.4% for treatment planning (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The addition of AI\u2010PD was associated with a 42.3% reduction in overtreatment risk (Steps 1\u20132 vs. Step 3) and a 98.5% reduction in the risk of tooth extraction (Step 3 vs. extraction).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When combined with radiographic information, PerioAI shows potential to provide incremental information for clinical decision making. Future research should integrate additional periodontal parameters and validate the approach in larger and more diverse populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70138","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:57:07Z","timestamp":1777877827000},"page":"1056-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Potential of the\n                    <scp>PerioAI<\/scp>\n                    System to Support Periodontal Clinical Decision Making: A Proof\u2010of\u2010Principle Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6592-7876","authenticated-orcid":false,"given":"Hairui","family":"Li","sequence":"first","affiliation":[{"name":"Shanghai Perio\u2010Implant Innovation Center and Oral Biomedical Intelligence Technology Laboratory (ORAL\u2010BIT Lab) Institute of Integrated Oral, Craniofacial and Sensory Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology, Shanghai Jiao Tong University National Center of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-7516","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Perio\u2010Implant Innovation Center and Oral Biomedical Intelligence Technology Laboratory (ORAL\u2010BIT Lab) Institute of Integrated Oral, Craniofacial and Sensory Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology, Shanghai Jiao Tong University National Center of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhui","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering &amp; State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering &amp; State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinggang","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering &amp; State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech University  Shanghai China"},{"name":"Shanghai United Imaging Intelligence Co., Ltd.  Shanghai China"},{"name":"Shanghai Clinical Research and Trial Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Roccuzzo","sequence":"additional","affiliation":[{"name":"Shanghai Perio\u2010Implant Innovation Center and Oral Biomedical Intelligence Technology Laboratory (ORAL\u2010BIT Lab) Institute of Integrated Oral, Craniofacial and Sensory Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology, Shanghai Jiao Tong University National Center of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology  Shanghai China"},{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-0137","authenticated-orcid":false,"given":"Maurizio S.","family":"Tonetti","sequence":"additional","affiliation":[{"name":"Shanghai Perio\u2010Implant Innovation Center and Oral Biomedical Intelligence Technology Laboratory (ORAL\u2010BIT Lab) Institute of Integrated Oral, Craniofacial and Sensory Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology, Shanghai Jiao Tong University National Center of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology  Shanghai China"},{"name":"European Research Group on Periodontology  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.3782"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64509-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2023.03.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2017-000198"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.04.011"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90406-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21056"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100348"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.17216"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.01.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.14152"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.010"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53758-2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44839-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13574"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-025-02077-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.14119"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260905.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb01960.x"},{"key":"e_1_2_10_21_1","unstructured":"Malpani R. 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