{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:49:00Z","timestamp":1790858940069,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether cycles of fasting\u2010mimicking diet (FMD), used as an adjunct to non\u2010surgical periodontal treatment, are feasible and could influence clinical and inflammatory responses, particularly with respect to C\u2010reactive protein (CRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Individuals with periodontitis were randomised to receive steps 1 and 2 of periodontal treatment, either following their regular diet (controls) or with three adjunctive 5\u2010day courses of FMD (test). Blood and gingival crevicular fluid (GCF) samples were collected to study the levels of inflammatory biomarkers, along with clinical parameters and patient\u2010reported outcome measurements (PROMs). All patients were followed up at days 1, 7, 45, 90 and 180 post treatment, and food diaries were completed. Exploratory repeated measures ANOVA and non\u2010parametric tests were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010seven patients completed the 6\u2010month follow\u2010up. Feasibility criteria were satisfied. Baseline serum high\u2010sensitivity (hs)\u2010CRP increased on Day 1 in both groups and then decreased. Exploratory longitudinal analyses indicated temporal changes in hs\u2010CRP and selected GCF biomarkers (including MMP\u20108, CRP, IL\u20106, IL\u20101\n                      <jats:italic>\u03b1<\/jats:italic>\n                      and IL\u20101\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ), with descriptive trends towards lower values at later time points in the FMD group observed for hs\u2010CRP, MMP\u20108 and IL\u20106. No inter\u2010group periodontal clinical differences were detected. Only minimal adverse events were reported in the FMD group, with no inter\u2010group differences in PROMs and clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Three cycles of FMD, adjunctive to step 2, were associated with a reduction of the inflammatory response after subgingival instrumentation, although these changes did not benefit clinical parameters. Given the exploratory nature of the analyses and the multiple comparisons performed, these findings should be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70139","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:01:14Z","timestamp":1781132474000},"page":"1254-1264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Fasting\u2010Mimicking Diet Affects the Inflammatory Response Following Periodontal Treatment: A Multi\u2010centre Feasibility Randomised Controlled Pilot Trial"],"prefix":"10.1111","volume":"53","author":[{"given":"Giuseppe","family":"Mainas","sequence":"first","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral &amp; Craniofacial Sciences King's College London  London 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Periodontology Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Pereira","family":"Couto","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlio","family":"Vinciguerra","sequence":"additional","affiliation":[{"name":"Department of Translational Stem Cell Biology, Research Institute Medical University of Varna  Varna Bulgaria"},{"name":"Department of Medicine and Surgery LUM University  Casamassima Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valter D.","family":"Longo","sequence":"additional","affiliation":[{"name":"Longevity Institute, Leonard Davis School of Gerontology, Department of Biological Sciences University of Southern California  Los Angeles California 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