{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:04:25Z","timestamp":1784174665879,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The oral microbiota has been implicated in mucosal immune regulation; however, its causal impact on salivary gland\u2013associated immune features remains incompletely understood. In this proof\u2010of\u2010concept study, germ\u2010free (GF) mice were colonised with salivary microbiota derived from either a periodontitis donor or a periodontally healthy donor, and IgA\u2010associated immune readouts were evaluated across multiple compartments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>GF mice were orally colonised with saliva\u2010derived microbiota from a periodontitis patient or a periodontally healthy donor (or PBS). Total IgA in saliva, serum and faeces were quantified by ELISA. Cervical lymph nodes and blood were analysed by flow cytometry. Submandibular glands underwent histology and bulk RNA\u2010seq.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mice receiving microbiota from a periodontitis donor exhibited altered IgA levels in saliva, serum and faeces, increased faecal lipocalin\u20102, changes in innate immune cell distributions and increased CD138\n                      <jats:sup>+<\/jats:sup>\n                      cell signals and IgA immunoreactivity in the submandibular glands. Transcriptomic analysis revealed heterogeneous expression of individual IgA\u2010related genes, with coordinated patterns observed at the level of IgA\/mucosal defence\u2013related gene sets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that salivary microbiota from a periodontitis donor are associated with altered IgA\u2010related immune features under GF conditions. While limited by the use of a single donor per group, this study provides proof\u2010of\u2010concept evidence supporting a potential role of oral microbiota in shaping salivary gland\u2013associated immune characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70146","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T07:19:14Z","timestamp":1779520754000},"page":"1355-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary Microbiota From a Periodontitis Donor Is Associated With Altered\n                    <scp>IgA<\/scp>\n                    \u2010Related Immune Features in Germ\u2010Free Mice"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1305-9876","authenticated-orcid":false,"given":"K.","family":"Irie","sequence":"first","affiliation":[{"name":"Department of Oral Health Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Community Oral Health School of Dentistry, Asahi University  Mizuho Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Minoshima","sequence":"additional","affiliation":[{"name":"Department of Oral Health Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Mochida","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry and Dental Public Health Kanagawa Dental University  Yokosuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Molecular Hematopathology Okayama University 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