{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:04:24Z","timestamp":1784174664117,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K10353"],"award-info":[{"award-number":["22K10353"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K16239"],"award-info":[{"award-number":["23K16239"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K13330"],"award-info":[{"award-number":["25K13330"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the longitudinal association between periodontitis and stroke onset using medical claims data and also to assess the relationship between periodontitis and stroke\u2010related medical costs and length of hospital stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In total, 1997 individuals aged 75 or 80\u2009years were included. The association between periodontitis and stroke onset over a 5\u2010year period was evaluated using a Cox proportional hazards model, with stroke onset as the dependent variable and periodontitis as the independent variable. Restricted mean survival time (RMST) was compared across periodontitis severity groups. In addition, generalised linear models were used to evaluate the relationships of periodontitis with stroke\u2010related medical costs and length of hospital stay among participants who experienced a stroke during the follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants with severe periodontitis had a significantly higher hazard ratio for stroke onset after 23\u2009months of follow\u2010up compared to those without periodontitis and exhibited a significantly reduced RMST for stroke onset. Among 80\u2010year\u2010old participants, those with periodontitis incurred significantly higher treatment costs and spent more days in health care compared to participants without periodontitis. No significant associations were observed among 75\u2010year\u2010old participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that periodontitis may be associated with the incidence and severity of stroke, potentially impacting the increased medical care costs associated with stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70153","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:44:26Z","timestamp":1781311466000},"page":"1323-1331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontitis and Stroke Onset, Medical Costs and Length of Hospital Stay: A 5\u2010Year Cohort Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9575-6817","authenticated-orcid":false,"given":"Mizuki","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Preventive Dentistry and Dental Public Health, School of Dentistry Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-3954","authenticated-orcid":false,"given":"Yoshihiro","family":"Shimazaki","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry and Dental Public Health, School of Dentistry Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Nonoyama","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry and Dental Public Health, School of Dentistry Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Inamoto","sequence":"additional","affiliation":[{"name":"Mie Dental Association  Tsu 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