{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:09:21Z","timestamp":1791227361078,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001014"],"award-info":[{"award-number":["82001014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071090"],"award-info":[{"award-number":["82071090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the role and epigenetic mechanism of methyltransferase 14 (METTL14)\u2010mediated N6\u2010adenylate methylation (m6A) modification of long non\u2010coding RNAs (lncRNAs) in the pathogenesis of periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A periodontal ligament\u2013targeted\n                      <jats:italic>Mettl14<\/jats:italic>\n                      \u2010cKO mouse model (\n                      <jats:italic>Gli1\u2010Cre<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>ERT2<\/jats:italic>\n                      <\/jats:sup>\n                      <jats:italic>;Mettl14<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>fl\/fl<\/jats:italic>\n                      <\/jats:sup>\n                      ) was established using silk ligatures. Human periodontal ligament cells (PDLCs) were used for in\u00a0vitro assays. MeRIP\u2010seq, RNA\u2010seq, RNA pull\u2010down, mass spectrometry, RIP Co\u2010IP and CUT&amp;Tag were performed to elucidate the METTL14\u2013NEAT1_2\u2013YBX1 axis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>METTL14 expression was significantly up\u2010regulated in inflamed periodontal tissue. METTL14 deficiency alleviated alveolar bone destruction and suppressed IL\u20106 expression in\u00a0vivo and in\u00a0vitro. Mechanistically, METTL14 catalysed m6A modification of nuclear paraspeckle assembly transcript 1_2 (NEAT1_2), facilitating NEAT1_2 degradation. NEAT1_2\u2010organised paraspeckles (PSPs) sequestered the transcription factor Y\u2010box binding protein 1 (YBX1) under normal conditions. In periodontitis, METTL14\u2010induced NEAT1_2 down\u2010regulation triggered PSP disassembly, resulting in the translocation of YBX1 to the nucleus and increased IL\u20106 transcription. Neat1_2 knockdown exacerbated bone loss and neutralised the protective effect of METTL14 deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>METTL14\u2010mediated m6A modification exacerbates periodontitis by disrupting NEAT1_2\u2010dependent PSP sequestration of YBX1. This study identifies the METTL14\u2013NEAT1_2 axis as a critical regulator of periodontal inflammation, suggesting that METTL14 is a potential therapeutic target for periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70155","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:04:57Z","timestamp":1781748297000},"page":"1621-1634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>METTL14<\/scp>\n                    \u2010Mediated\n                    <scp>m6A<\/scp>\n                    Modification of\n                    <scp>NEAT1_2<\/scp>\n                    Releases\n                    <scp>YBX1<\/scp>\n                    From Paraspeckles to Exacerbate Periodontitis"],"prefix":"10.1111","volume":"53","author":[{"given":"Juan","family":"Du","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi'ang","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology Wuhan University  Wuhan 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