{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:45:46Z","timestamp":1791859546582,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32501039"],"award-info":[{"award-number":["32501039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32400967"],"award-info":[{"award-number":["32400967"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To elucidate the influence and mechanism of extracellular vesicles (EVs) derived from brain tissue with ageing regulating alveolar bone resorption in periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>EVs secreted by young brain tissue (YBEVs) were assessed in a periodontitis model. Further, macrophages were treated with YBEVs or lipopolysaccharide in\u00a0vitro. RNA sequencing and proteomic analysis were performed to explore how YBEVs influenced inflammatory macrophages, and the expression of peroxiredoxin 3 (PRDX3) as well as of NF\u2010\u03baB pathway\u2010related factors was detected by Western blotting. PRDX3 modulators were employed to explore the NF\u2010\u03baB pathway's impact on inflammatory macrophage in\u00a0vitro and in\u00a0vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>YBEVs suppressed the inflammatory response in macrophages in\u00a0vitro and reduced inflammation and bone resorption in\u00a0vivo. Multi\u2010omics analyses, including cellular transcriptomics, vesicular cargo transcriptomics and single\u2010cell profiling of brain tissue, together with in\u00a0vitro and in\u00a0vivo experiments, suggested that YBEVs modulated the immune response and the NF\u2010\u03baB signalling pathway implicating PRDX3 as a key effector.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>By delivering PRDX3 and inhibiting the activation of the NF\u2010\u03baB pathway, YBEVs inhibit inflammatory macrophages and decrease alveolar bone loss. This study provides new insight into the association between the brain and age\u2010related periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70158","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:45:35Z","timestamp":1782809135000},"page":"1722-1734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracellular Vesicles From Young Brain\u2013Mediated Delivery of PRDX3 Ameliorates Alveolar Bone Loss in Periodontitis"],"prefix":"10.1111","volume":"53","author":[{"given":"Jiajie","family":"Mao","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases  Hangzhou China"},{"name":"Zhejiang\u2013Singapore International Joint Laboratory of Oral Bioengineering, Zhejiang Clinovation Pride  Hangzhou 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