{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T01:24:55Z","timestamp":1786929895652,"version":"build-2736575974"},"reference-count":75,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the periodontal condition of individuals with different susceptibility to dental biofilm\u2013induced gingivitis 25\u2009years after their classification as high responders (HR) or low responders (LR) to plaque.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010eight systemically and periodontally healthy young adults who participated in a 21\u2010day experimental gingivitis trial in 2000\u20132001 and exhibited either markedly pronounced (HR,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) or milder (LR,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) gingival inflammation despite similar supragingival plaque exposure were invited to a follow\u2010up visit, during which a periodontal diagnosis was established.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine LR and eight HR individuals accepted to participate. Among the LR participants, six (67%) were diagnosed as periodontally healthy or with gingivitis, whereas 100% of HR participants were diagnosed with periodontitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Compared to LR, HR individuals presented higher bleeding on probing score (39.5%\u2009\u00b1\u200913.8% vs. 15.0%\u2009\u00b1\u200910.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) as well as a higher proportion of visibly inflamed sites (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Intergroup differences could not be explained by other variables, including full\u2010mouth plaque score, oral hygiene habits or adherence to supportive care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study, based on a very limited sample size and therefore hypothesis\u2010generating rather than confirmatory, suggests that susceptibility to biofilm\u2010induced gingivitis may help identify individuals at different risks of periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70163","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:25:24Z","timestamp":1784528724000},"page":"1393-1402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Twenty\u2010Five\u2010Year Follow\u2010Up of Individuals With Intact Periodontium and Differing Susceptibility to Experimentally Induced Gingival Inflammation"],"prefix":"10.1111","volume":"53","author":[{"given":"Leonardo","family":"Trombelli","sequence":"first","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010Implant Diseases University of Ferrara  Ferrara Italy"},{"name":"Operative Unit of Dentistry Azienda Unit\u00e0 Sanitaria Locale (AUSL)  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Guidorzi","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010Implant Diseases University of Ferrara  Ferrara Italy"},{"name":"Operative Unit of Dentistry Azienda Unit\u00e0 Sanitaria Locale (AUSL)  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6327-3610","authenticated-orcid":false,"given":"Dimitris N.","family":"Tatakis","sequence":"additional","affiliation":[{"name":"Periodontics Department, College of Dentistry Texas A&amp;M University  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4621-7809","authenticated-orcid":false,"given":"Roberto","family":"Farina","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010Implant Diseases University of Ferrara  Ferrara Italy"},{"name":"Operative Unit of Dentistry Azienda Unit\u00e0 Sanitaria Locale (AUSL)  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1986.tb00881.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12420"},{"key":"e_1_2_9_4_1","first-page":"229","article-title":"Problems and Proposals for Recording Gingivitis and Plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/43.3-4.461"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1981.tb02039.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012578118"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752\u20107163\/ae4377"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021508"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0719"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12366"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10149"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608501213"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa209"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457373"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010024\u201006125\u2010z"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.70083"},{"key":"e_1_2_9_19_1","article-title":"Sexual Dimorphism in Geriatric Periodontology and Implant Dentistry","author":"Farina R.","year":"2026","journal-title":"Minerva Dental and Oral Science"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00234"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2018.06.006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01285.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1975.tb01734.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S564132"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1994.tb00737.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140589"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1986.tb00852.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1990.tb01059.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2018.02.014"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12317"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1965.36.3.177"},{"key":"e_1_2_9_33_1","volume-title":"Textbook of Periodontia (Oral Medicine)","author":"Miller S. C.","year":"1950"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2021.105184"},{"key":"e_1_2_9_35_1","article-title":"Beyond Biologic Sex: Hormonal and Contextual Drivers of Periodontal and Peri\u2010Implant Outcomes","author":"Neapole C.","year":"2026","journal-title":"Periodontology 2000"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012049.pub2"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.5154"},{"issue":"3","key":"e_1_2_9_39_1","first-page":"235","article-title":"Pathogenesis of Inflammatory Periodontal Disease. A Summary of Current Work","volume":"34","author":"Page R. C.","year":"1976","journal-title":"Laboratory Investigation"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17\u20100721"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12569"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13690"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12782"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.1.49"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2007.01145.x"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2004.00634.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u2010051x.2003.00414.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516668847"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13346"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100044"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201093062\u20106"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.7.1067"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u2010789X.2010.00808.x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02943-6"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010025\u201005702\u20102"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.2004.00477.x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.1966.tb01842.x"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18\u20100006"},{"issue":"1","key":"e_1_2_9_59_1","first-page":"265","article-title":"Susceptibility to Gingivitis: A Way to Predict Periodontal Disease?","volume":"2","author":"Trombelli L.","year":"2004","journal-title":"Oral Health & Preventive Dentistry"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.70041"},{"issue":"6","key":"e_1_2_9_61_1","first-page":"207","article-title":"A Review of Factors Influencing the Incidence and Severity of Plaque\u2010Induced Gingivitis","volume":"62","author":"Trombelli L.","year":"2013","journal-title":"Minerva Stomatologica"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2010.01573.x"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2005.00835.x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2005.00873.x"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2006.00914.x"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.2004.00478.x"},{"key":"e_1_2_9_67_1","first-page":"368","volume-title":"Clinical Periodontology and Implant Dentistry","author":"Trombelli L.","year":"2021"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12939"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2008.01315.x"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300914"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1985.tb01354.x"},{"issue":"1","key":"e_1_2_9_72_1","first-page":"6","article-title":"Uber den Einfluss der Parodontalen Resistenz Auf Die Experimentelle Gingivitis [the Effect of Periodontal Resistance on Experimental Gingivitis]","volume":"34","author":"Wiedemann W.","year":"1979","journal-title":"Deutsche zahn\u00e4rztliche Zeitschrift"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1987.tb00990.x"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12633"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010025\u201006282\u20109"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2024.01.003"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.70163","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.70163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:58:18Z","timestamp":1786928298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.70163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,19]]},"references-count":75,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jcpe.70163"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.70163","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,19]]},"assertion":[{"value":"2026-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}