{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T01:24:56Z","timestamp":1786929896164,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016070","name":"ITI Foundation","doi-asserted-by":"publisher","award":["937_2014"],"award-info":[{"award-number":["937_2014"]}],"id":[{"id":"10.13039\/501100016070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401062"],"award-info":[{"award-number":["82401062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030982","name":"Straumann Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the peri\u2010implant soft\u2010tissue and hard\u2010tissue response to monolithic zirconia (ZrO\n                      <jats:sub>2<\/jats:sub>\n                      ) compared to porcelain\u2010fused\u2010to\u2010metal implant crowns (PFMs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This report constitutes a pre\u2010specified secondary analysis of this RCT. Eighty\u2010three patients rehabilitated with single\u2010tooth implants in the molar region were originally randomly assigned to receive either a ZrO\n                      <jats:sub>2<\/jats:sub>\n                      or a PFM restoration. At 6\u2009months, clinical parameters (plaque control record, probing depth, bleeding on probing, width of keratinised mucosa and marginal bone level changes) were recorded at the implant site and the adjacent natural tooth. In addition, a peri\u2010implant soft\u2010tissue biopsy specimen was harvested between the implant site and the adjacent tooth. The number of inflammatory cells and fibroblasts\/fibrocytes was evaluated within four regions of interest (oral epithelium, sulcular epithelium, junctional epithelium, connective tissue). Descriptive statistics were arrived at for all outcomes, and differences between prosthetic materials, sites and timepoints were analysed using linear mixed\u2010effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The present exploratory secondary analysis included 67 patients (37 ZrO\n                      <jats:sub>2<\/jats:sub>\n                      ; 30 PFM) with complete 6\u2010month clinical, radiographic and histological data. Clinical parameters at both implant and adjacent tooth sites remained generally stable from baseline to 6\u2009months, with limited marginal bone level changes and comparable outcomes between groups. Histologically, mixed\u2010effects model analysis showed that the tissue region significantly affected both the inflammatory infiltrate and the fibroblast density (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The crown materials did not substantially influence the histological outcomes. The distribution of inflammatory infiltrate differed between tooth and implant sites, with the highest values in the sulcular epithelium around implants and in the junctional epithelium around teeth. Fibroblast density was highest in the junctional epithelium at both sites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Monolithic zirconia and PFM implant\u2010supported single crowns resulted in comparable clinical and radiographic outcomes. The peri\u2010implant soft\u2010tissue response to the two restorative materials showed a greater effect of the tissue region, while the material itself had only negligible effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT02272491\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70169","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:14:33Z","timestamp":1784160873000},"page":"1423-1433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peri\u2010Implant Soft Tissue Response to Monolithic Zirconia Versus Porcelain\u2010Fused\u2010to\u2010Metal Implant Crowns: Histological and Clinical Outcomes of an\n                    <scp>RCT<\/scp>"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0701-3771","authenticated-orcid":false,"given":"Yifan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Implantology Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"},{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-1813","authenticated-orcid":false,"given":"Sven","family":"M\u00fchlemann","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich  Zurich Switzerland"},{"name":"Private Practice  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aspasia","family":"Pachiou","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Astrid","family":"Stalder","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Implantology Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel S.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich  Zurich Switzerland"},{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry  Seoul Republic of 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