{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:25:27Z","timestamp":1791465927247,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess 10\u2010year implant survival following surgical management of peri\u2010implantitis using deproteinised bovine bone mineral with 10% collagen (DBBMC), enamel matrix derivative (EMD) and doxycycline powder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The original population comprised 30 non\u2010smoking, periodontally stable patients (mean age\u2009=\u200944.9\u2009\u00b1\u200911\u2009years; 64% female; full\u2010mouth plaque and bleeding score &lt;\u200920%, no bleeding residual periodontal pockets \u2265\u20094\u2009mm), each with a single peri\u2010implantitis\u2010affected implant (bleeding on probing, probing depth &gt;\u20096\u2009mm, \u2265\u200920% radiographic bone loss, implants in function \u2265\u20092\u2009years). The surgical procedure involved implant surface decontamination with 24% EDTA followed by defect fill with DBBMC\/EMD\/doxycycline mixture. Patients underwent individualised supportive peri\u2010implant therapy (SPIT) comprising regular clinical monitoring, professional cleaning and antimicrobial protocols for 10\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010nine of the 30 implants survived (96.6% survival rate). Mean probing depth decreased from 8.90\u2009\u00b1\u20091.9\u2009mm to 3.06\u2009\u00b1\u20090.98\u2009mm; radiographic bone loss improved from 57%\u2009\u00b1\u200916.5% to 13%\u2009\u00b1\u20092.5%. During 10\u2010year SPIT, 12 implants required adjunctive azithromycin. Fifty\u2010eight percent achieved the successful treatment outcome criterion (SOTC: probing depth &lt;\u20095\u2009mm, no bone loss 10% from baseline, absence of bleeding on probing\/suppuration and recession &lt;\u20090.5\u2009mm anterior\/1.5\u2009mm posterior implants).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surgical management of peri\u2010implantitis combined with DBBMC\/EMD\/doxycycline and personalised SPIT achieved high long\u2010term implant survival and stable clinical outcomes over 10\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70175","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:21:57Z","timestamp":1784848917000},"page":"1575-1584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Surgical Therapy for 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