{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:04:01Z","timestamp":1789610641311,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014840","name":"Gemeinsame Bundesausschuss","doi-asserted-by":"publisher","award":["01VSF21026"],"award-info":[{"award-number":["01VSF21026"]}],"id":[{"id":"10.13039\/501100014840","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the efficacy of a digital health companion app as an adjunct to systematic periodontal therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seven German university dental centres conducted this multi\u2010centre randomised controlled trial. Adults with periodontitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009194) were assigned to standard periodontal care with or without the Paro\u2010ComPas app. The primary endpoint was the gingival bleeding index (GBI) at baseline, re\u2010evaluation and during supportive periodontal care. Secondary outcomes included plaque and bleeding on probing. Confirmatory analyses used longitudinal mixed\u2010effects regression. Exploratory analyses examined clinical outcomes by app usage cluster.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 180 participants, 148 completed the trial. Both groups showed substantial clinical improvements. The unadjusted between\u2010group difference favoured the control group [7.70\u2009pp (0.55; 14.85) at T0\u2013T2]; the adjusted analysis showed no significant difference in the primary endpoint (1.56\u2009pp;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.352) or in secondary endpoints. Implementation fidelity was suboptimal. Exploratory analyses revealed that moderate app users achieved significantly greater plaque reductions compared to low users (\u221214.95\u2009pp;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This trial found no significant benefit of a digital companion app as an adjunct to systematic periodontal therapy. Low baseline inflammation, incomplete intervention delivery and inter\u2010examiner variability likely limited detection of small effects. Exploratory findings suggest potential benefits among moderately engaged users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The study was registered in an international trial register (German Clinical Trial Register number DRKS00031263, registration date 19\/06\/2023,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.drks.de\/search\/de\/trial\/DRKS00031263\/details\">https:\/\/www.drks.de\/search\/de\/trial\/DRKS00031263\/details<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70181","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:06:25Z","timestamp":1785452785000},"page":"1596-1609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of a Digital Companion in Periodontal Care: A Randomised Controlled Trial"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-0479","authenticated-orcid":false,"given":"Bettina","family":"Dannewitz","sequence":"first","affiliation":[{"name":"Center for Dentistry and Oral Medicine (Carolinum), Department of Periodontology Goethe\u2010University Frankfurt am Main  Frankfurt am Main Germany"},{"name":"Private Dental Practice  Weilburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-1885","authenticated-orcid":false,"given":"James","family":"Deschner","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Operative Dentistry University Medical Centre of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-8075","authenticated-orcid":false,"given":"Christof","family":"D\u00f6rfer","sequence":"additional","affiliation":[{"name":"Clinic for Conservative Dentistry and Periodontology University Medical Centre Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-2651","authenticated-orcid":false,"given":"Henrik","family":"Dommisch","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Oral Medicine and Oral Surgery Charit\u00e9 \u2013 University Medicine  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-8055","authenticated-orcid":false,"given":"Peter","family":"Eickholz","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Medicine (Carolinum), Department of Periodontology Goethe\u2010University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Preventive and Restorative Dentistry University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7155-6522","authenticated-orcid":false,"given":"Lukasz","family":"Jablonowski","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0172-0133","authenticated-orcid":false,"given":"Neelam","family":"Lingwal","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Medicine (Carolinum) Goethe\u2010University Frankfurt Am Main  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Listl","sequence":"additional","affiliation":[{"name":"Heidelberg Institute of Global Health, Section for Oral Health Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"R\u00fctters","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Section of Periodontology, Clinic for Oral, Dental and Maxillofacial Diseases Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-1267","authenticated-orcid":false,"given":"Lina","family":"Weinert","sequence":"additional","affiliation":[{"name":"Heidelberg Institute of Global Health, Section for Oral Health Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1124-6506","authenticated-orcid":false,"given":"Nihad","family":"El Sayed","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Medicine (Carolinum), Department of Periodontology Goethe\u2010University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Paro\u2010ComPas 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