{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:46:12Z","timestamp":1785732372504,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF230C0084173"],"award-info":[{"award-number":["NNF230C0084173"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007417","name":"Paulon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["340750"],"award-info":[{"award-number":["340750"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["369310"],"award-info":[{"award-number":["369310"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether periodontitis stage and grade are associated with circulating active lipid mediators and whether baseline lipid species predict periodontitis progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The study included 473 Finnish participants from the Parogene cohort undergoing coronary angiography, with 12\u2010year follow\u2010up data available for 117 individuals. Periodontal status was assessed clinically and radiographically. Plasma ceramides (Cer) and phosphocholines (PC) were quantified by LC\u2010MS\/MS, and cardiovascular risk scores (CERT1 and CERT2) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Several Cer:Cer and Cer:PC ratios increased with periodontitis stage, grade and edentulousness, whereas most PC species decreased. Cer(d18:1\/16:0)\/PC(16:0\/22:5), Cer(d18:1\/18:0)\/Cer(d18:1\/24:0), Cer(d18:1\/18:0)\/PC(16:0\/22:5) and Cer(d18:1\/24:1)\/PC(16:0\/22:5) were associated with all periodontal measures. CERT2 was independently associated with both stage and grade. In cross\u2010sectional analyses, periodontitis was associated with multiple lipid species both directly and indirectly through systemic inflammation. In longitudinal analyses, baseline lipid levels did not predict periodontitis progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Periodontitis severity was found to be associated with systemic ceramide and phospholipid profiles, particularly Cer:PC ratios, whereas baseline lipid levels were not associated with subsequent disease progression. These findings suggest that systemic inflammation substantially mediates the relationship between periodontitis and circulating lipid species, linking periodontitis with broader disturbances in lipidomic homeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70182","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:22:58Z","timestamp":1785730978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Lipidomics Identifies Altered Ceramide\u2013Phospholipid Balance Associated With Periodontitis Severity: A Cross\u2010Sectional Study With 12\u2010Year Follow\u2010Up"],"prefix":"10.1111","author":[{"given":"Minja","family":"Tuomivaara","sequence":"first","affiliation":[{"name":"School of Medicine, Institute of Dentistry University of Eastern Finland  Kuopio 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