{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:47:08Z","timestamp":1785833228756,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019921","name":"Geistlich Pharma","doi-asserted-by":"publisher","award":["Material Transfer Agreement N 15\u2010015"],"award-info":[{"award-number":["Material Transfer Agreement N 15\u2010015"]}],"id":[{"id":"10.13039\/501100019921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005922","name":"International Association for Dental Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005922","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To clinically and radiologically evaluate the healing capacity of intrabony periodontal defects treated with guided tissue regeneration (GTR) with or without the combination of orthodontic tooth movement (OTM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010four individuals presenting with periodontal intrabony defects (IDs) and pathological tooth migration (PTM) were included in this randomised controlled clinical trial. Extended, coronally advanced flaps and GTR (collagen membrane and bovine bone mineral) were used to treat IDs. After surgery, patients were randomly allocated to either the test group (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u200917) with an early (1\u2009week postoperatively) initiation of OTM or the control group (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u200917) without any tooth movement. Outcome variables comprised changes in clinical attachment level (CAL), probing pocket depth (PPD), gingival recession (GR), probing bone level and intrabony component (IC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both groups yielded statistically significant CAL gain (4.0\u2009\u00b1\u20092.0\u2009mm in the test group and 4.4\u2009\u00b1\u20091.3\u2009mm in the control group) and PPD reduction (3.9\u2009\u00b1\u20091.4 and 4.9\u2009\u00b1\u20091.7\u2009mm, respectively) as well as IC reduction. However, only the control group showed a significant increase in GR and crestal bone loss from baseline to the endpoint. The change in IC was\u2009\u22124.3\u2009\u00b1\u20092.0\u2009mm in the test group and\u2009\u22124.6\u2009\u00b1\u20091.8\u2009mm in the control group, corresponding to 66% and 64.5% intrabony fill, respectively. All evaluated parameters showed comparable changes between the two groups, with no evidence of clinically meaningful differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GTR combined with OTM resulted in similar clinical endpoint parameters after 9\u2009months of healing compared with GTR alone. This clinical result confirms the histological findings (Part I article) that early initiation of OTM is feasible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70183","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:25:58Z","timestamp":1785831958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Orthodontic Tooth Movement on Intrabony Periodontal Defects After Guided Tissue Regeneration. Part\n                    <scp>II<\/scp>\n                    : The Evaluation of Clinical and Radiological Parameters in a Randomised Controlled Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5452-7666","authenticated-orcid":false,"given":"Pal","family":"Nagy","sequence":"first","affiliation":[{"name":"Department of Periodontology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-683X","authenticated-orcid":false,"given":"Andrea","family":"Dobos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balint","family":"Nemes","sequence":"additional","affiliation":[{"name":"Department of Paedodontics and Orthodontics Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztian","family":"Kover","sequence":"additional","affiliation":[{"name":"Department of Periodontology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Windisch","sequence":"additional","affiliation":[{"name":"Department of Periodontology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"17","article-title":"Regenerative Therapy of Osseous Defects Combined With Orthodontic Tooth Movement","volume":"14","author":"Attia M. 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