{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:45:47Z","timestamp":1791859547230,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare clinical outcomes and patient\u2010reported outcome measures (PROMs) of palatal donor\u2010site healing following the use of an absorbable gelatine sponge, a chitosan sponge or an injectable platelet\u2010rich fibrin (i\u2010PRF)\u2010enriched chitosan sponge after free gingival graft harvesting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this three\u2010arm randomised controlled clinical study, a total of 68 patients were allocated to three groups: i\u2010PRF\u2009+\u2009chitosan (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), chitosan (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) and gelatine sponge (control;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923). The primary outcome was the palatal early healing index (PEHI). Secondary outcomes included PROMs, namely postoperative pain, burning sensation and changes in dietary habits, which were evaluated using a visual analogue scale (VAS) at postoperative days 7, 14, 28 and 56. Bleeding and painkiller consumption were recorded daily. Colour match was assessed using VAS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both chitosan\u2010containing groups showed significantly higher PEHI scores, particularly on days 14 and 28, than the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). At Day 14, the median PEHI scores were 8.0 (Q1\u2013Q3: 7.0\u20138.0; 95% CI for the median: 7.0\u20138.0), 8.0 (Q1\u2013Q3: 8.0\u20139.0; 95% CI: 8.0\u20139.0) and 9.0 (Q1\u2013Q3:8.0\u20139.0; 95% CI: 8.0\u20139.0) in the control, chitosan and i\u2010PRF\u2010enriched chitosan groups, respectively. The i\u2010PRF\u2009+\u2009chitosan group showed significantly lower pain and burning sensation during early healing and less changes on dietary habits on days 3 and 7 compared with the other groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Bleeding and painkiller consumption were similar among groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Both test groups showed significantly better colour match than the control group at days 14, 28 and 56 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within the limitations of the present study, chitosan improved early palatal wound healing, while the addition of i\u2010PRF enhanced patient comfort. Both chitosan\u2010containing approaches resulted in improved colour match compared with control. Nevertheless, further studies incorporating histological and biomolecular assessments of wound healing are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70194","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T05:57:43Z","timestamp":1787551063000},"page":"1702-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Palatal Donor\u2010Site Healing and Patient\u2010Reported Outcome Measures Following Chitosan and Injectable Platelet\u2010Rich Fibrin\u2010Enriched Chitosan Application Compared with Gelatine Sponge: A Three\u2010Arm Randomised Controlled Clinical Trial"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-3562","authenticated-orcid":false,"given":"Ayse Ege","family":"Selman","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Biruni University  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-5896","authenticated-orcid":false,"given":"Bahar","family":"Alkaya","sequence":"additional","affiliation":[{"name":"Department of Periodontology Cukurova University  Adana Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-3896","authenticated-orcid":false,"given":"Burcu","family":"Karaduman","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Biruni University  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-553X","authenticated-orcid":false,"given":"Mustafa","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Cukurova University  Adana Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-3667","authenticated-orcid":false,"given":"Mehmet Cenk","family":"Haytac","sequence":"additional","affiliation":[{"name":"Department of Periodontology Cukurova University  Adana 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