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Additionally, OECs were stimulated with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>S. sanguinis<\/jats:italic>\n                      <\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>P. gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      and\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">F. nucleatum<\/jats:styled-content>\n                        ,\n                      <\/jats:italic>\n                      as well as with bacterial communities from the three conditions. STAT3 pathway\u2013associated mRNA levels and the pSTAT3\/STAT3 ratio were evaluated. Finally, the effect of pSTAT3 inhibition was analysed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Increased STAT3 pathway activation was observed in peri\u2010implantitis tissues, characterised by a higher pSTAT3\/STAT3 ratio and elevated\n                      <jats:italic>IL6<\/jats:italic>\n                      and\n                      <jats:italic>SOCS3<\/jats:italic>\n                      mRNA levels. Compared with healthy gingival tissues and periodontitis, peri\u2010implantitis tissues exhibit a higher proportion of pSTAT3\u2010positive epithelial cells.\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>P. gingivalis<\/jats:italic>\n                      <\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>F. nucleatum<\/jats:italic>\n                      <\/jats:styled-content>\n                      increased the mRNA of the STAT3\u2010associated\n                      <jats:italic>IL6<\/jats:italic>\n                      ,\n                      <jats:italic>IL23A<\/jats:italic>\n                      ,\n                      <jats:italic>SOCS3<\/jats:italic>\n                      , chemoattractant\u2010associated\n                      <jats:italic>CXCL8<\/jats:italic>\n                      ,\n                      <jats:italic>IL36G<\/jats:italic>\n                      and inflammation\u2010associated\n                      <jats:italic>IL1B<\/jats:italic>\n                      ,\n                      <jats:italic>TNF<\/jats:italic>\n                      A. Notably, STAT3 inhibition decreased the mRNA levels of STAT3\u2010downstream cytokines and the neutrophil chemoattractants\n                      <jats:italic>CXCL8<\/jats:italic>\n                      and\n                      <jats:italic>IL36G<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The STAT3 pathway is activated in peri\u2010implantitis and in OECs and is elicited by peri\u2010implantitis\u2010associated bacteria, contributing to a pro\u2010chemotactic epithelial environment, positioning this pathway as a key area of interest for future research into the molecular mechanisms underlying both conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.70199","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:10:16Z","timestamp":1788999016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peri\u2010Implantitis\u2010Associated Bacteria Activate the\n                    <scp>STAT3<\/scp>\n                    Pathway in Oral Epithelial Cells"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-9405","authenticated-orcid":false,"given":"Marion","family":"Arce","sequence":"first","affiliation":[{"name":"Laboratory of Oral Microbiology and Immunology, Faculty of Dentistry University of Chile  Santiago Chile"},{"name":"Clinical Research Unit in Periodontology and Implants, Faculty of Dentistry University of Chile  Santiago Chile"},{"name":"Department of Conservative Dentistry, Faculty of Dentistry University of Chile  Santiago Chile"},{"name":"ETEP Research Group, Faculty 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